publication . Article . 2011

Globalization of Alzheimer's disease clinical trials

Jeffrey Cummings; Robert Reynders; Kate Zhong;
  • Published: 01 Aug 2011
  • Publisher: Springer Nature
Abstract
Alzheimer's disease (AD) therapies are increasingly being tested in global clinical trials. A search of ClincalTrials.gov revealed that of 269 currently active trials, 28% are currently being conducted in the United States; the majority of trials and the majority of trial sites are ex-US. The US has the largest number of trial sites of any single country; cumulatively, nearly half of all sites are outside the US. The US conducts more trials in all phases of drug development but has a greater proportion of phase 3 trials. The increasing importance of global participants in clinical trials emphasizes the importance of considering the ethnic and international facto...
Subjects
free text keywords: Review, Cognitive Neuroscience, Neurology, Clinical Neurology, Sophistication, media_common.quotation_subject, media_common, Disease, Clinical trial, Psychiatry, medicine.medical_specialty, medicine, Gerontology, Geriatric psychiatry, Drug development, business.industry, business, Alternative medicine, Ethnic group, Risk factor
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47 references, page 1 of 4

Wimo, A, Prince, M. World Alzheimer Report 2010: The Global Economic Impact of Dementia. 2010

Phelps, K, Kumar, V. A new global view. The use of foreign data in INDs requires rethinking clinical trials. Drug Discov Dev. 2011: 30-32

Maiti, RMR. Clinical trials in India. Pharmacol Res. 2007; 56: 1-10 [OpenAIRE] [PubMed] [DOI]

Chui, HF, Lam, LC. Relevance of outcome measures in different cultural groups - does one size fit all?. Int Psychogeriatr. 2007; 19: 457-466 [PubMed] [DOI]

The World Medicines Situation. 2004

Glickman, SW, McHutchinson, JG, Peterson, ED, Cairns, CB, Harington, RA, Calif, RM, Schulman, KA. Ethical and scientific implications of the globalization of clinical research. N Engl J Med. 2009; 360: 816-823 [PubMed] [DOI]

Karlberg, JPE. The Establishment of Emerging Trial Regions. Clinical Trial Magnifier. 2011; 4: 7-23

Cummings, JL. What can be inferred from the interruption of the semagacestat trial for treatment of Alzheimer's disease?. Biol Psychiatry. 2010; 68: 876-878 [OpenAIRE] [PubMed] [DOI]

International Conference on Harmonisation; Guidance on Ethnic Factors in the Acceptability of Foreign Clinical Data; Availability. Federal Register. 1998; 63: 31790-31796 [PubMed]

The Real Wealth of Nations: Pathways to Human Development. 2010

Wu, CC, Yeh, WT, Crow, RS, Bai, CH, Pan, WH. Comparison of electrocardiographic findings and associated risk factors between Taiwan Chinese and US White adults. Int J Cardiol. 2008; 128: 224-231 [OpenAIRE] [PubMed] [DOI]

Education Level Statistics.

Wang, H, Yu, X, Li, S, Chen, Y, Li, H, He, J. The Cognitive Subscale of Alzheimer's Assessment Scale, Chinese version in staging of Alzheimer disease. Alzheimer Dis Assoc Disord. 2004; 18: 231-235 [PubMed]

Petersen, RC, Aisen, PS, Beckett, LA, Donohue, MC, Gamst, AC, Harvery, DJ, Jack, CR, Jugust, WJ, Shaw, LM, Toga, AW, Trojanowski, JQ, Weiner, MW. Alzheimer's Disease Neuroimaging Initiative (ADNI): clinical characterization. Neurology. 2010; 74: 201-209 [OpenAIRE] [PubMed] [DOI]

Stern, Y, Albert, S, Tang, MX, Tsai, WY. Rate of memory decline in AD is related to education and occupation. Neurology. 1999; 53: 1942-1947 [PubMed]

47 references, page 1 of 4
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