publication . Other literature type . Article . 2002

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

John Hardy; Dennis J Selkoe;
  • Published: 19 Jul 2002
  • Publisher: American Association for the Advancement of Science (AAAS)
Abstract
It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid beta-peptide (Abeta) in plaques in brain tissue. According to the amyloid hypothesis, accumulation of Abeta in the brain is the primary influence driving AD pathogenesis. The rest of the disease process, including formation of neurofibrillary tangles containing tau protein, is proposed to result from an imbalance between Abeta production and Abeta clearance
Subjects
Medical Subject Headings: mental disordersnervous system diseases
free text keywords: Multidisciplinary, Internal medicine, medicine.medical_specialty, medicine, PSEN1, P3 peptide, Biochemistry of Alzheimer's disease, BACE1-AS, Alzheimer's disease, medicine.disease, business.industry, business, Endocrinology, Neuroscience, Amyloid beta, biology.protein, biology, Amyloid precursor protein, Senile plaques
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