publication . Article . Other literature type . 2000

Association Mapping in Structured Populations

Pritchard, JK; Stephens, M; Rosenberg, NA; Donnelly, P;
Open Access
  • Published: 01 Jul 2000 Journal: The American Journal of Human Genetics, volume 67, issue 1, pages 170-181 (issn: 0002-9297, Copyright policy)
  • Publisher: Elsevier BV
  • Country: United Kingdom
Abstract
The use, in association studies, of the forthcoming dense genomewide collection of single-nucleotide polymorphisms (SNPs) has been heralded as a potential breakthrough in the study of the genetic basis of common complex disorders. A serious problem with association mapping is that population structure can lead to spurious associations between a candidate marker and a phenotype. One common solution has been to abandon case-control studies in favor of family-based tests of association, such as the transmission/disequilibrium test (TDT), but this comes at a considerable cost in the need to collect DNA from close relatives of affected individuals. In this article we...
Subjects
free text keywords: Genetics(clinical), Genetics, Articles, Gene mapping, Genetic marker, Single-nucleotide polymorphism, Genetic association, Linkage disequilibrium, Association mapping, Population, education.field_of_study, education, Biology, Population stratification
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