publication . Article . 1997

METABOLISM OF ARSENIC AFTER ACUTE OCCUPATIONAL ARSINE INTOXICATION

Pietro Apostoli; Lorenzo Alessio; Luciano Romeo; Jean Paul Buchet; Roberto Leone;
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  • Published: 01 Nov 1997 Journal: Journal of Toxicology and Environmental Health, volume 52, pages 331-342 (issn: 0098-4108, eissn: 1087-2620, Copyright policy)
  • Publisher: Informa UK Limited
Abstract
Among the elements of toxicological relevance, inorganic arsenic (As) probably exhibits the most complex metabolism, and we deemed it interesting to identify and quantify the different As species excreted after an occupational acute intoxication with arsine. For this purpose total Ar and five As species were determined using an hybrid analytical method coupling liquid chromatography with inductively coupled plasma mass spectrometry. The highest urinary elimination of total As was observed in the first 5 d after admission. The As species mostly excreted were monomethylarsonate (MMA), dimethylarsinate (DMA), Ar3+ arsenobetaine (AsB), and to a lesser extent As5+. T...
Subjects
free text keywords: Toxicology, Pollution, Health, Toxicology and Mutagenesis, Arsenobetaine, chemistry.chemical_compound, chemistry, Metabolism, Urine, Chromatography, Arsenic, chemistry.chemical_element, Arsine, Toxicokinetics, High-performance liquid chromatography, Excretion
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