publication . Article . 2016

Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Do-Geun Kim; Antje Krenz; Leon E. Toussaint; Kirk J. Maurer; Sudie-Ann Robinson; Angela Yan; Luisa Torres; Margaret S. Bynoe;
Open Access English
  • Published: 05 Jan 2016 Journal: Journal of Neuroinflammation, volume 13, issue 1 (issn: 1742-2094, Copyright policy)
  • Publisher: Springer Nature
Abstract
Background Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease afflicting about one third of the world’s population and 30 % of the US population. It is induced by consumption of high-lipid diets and is characterized by liver inflammation and subsequent liver pathology. Obesity and consumption of a high-fat diet are known to increase the risk of Alzheimer’s disease (AD). Here, we investigated NAFLD-induced liver inflammation in the pathogenesis of AD. Methods WT and APP-Tg mice were fed with a standard diet (SD) or a high-fat diet (HFD) for 2, 5 months, or 1 year to induce NAFLD. Another set of APP-Tg mice were removed from HFD after 2 months an...
Subjects
free text keywords: Immunology, Cellular and Molecular Neuroscience, Neurology, Research, Alzheimer’s disease, Apolipoprotein E, High-fat diet, Non-alcoholic fatty liver disease, Standard diet, General Neuroscience, Alcoholic fatty liver, Endocrinology, medicine.medical_specialty, medicine, Chronic liver disease, medicine.disease, Pathogenesis, Fatty liver, Inflammation, medicine.symptom, Cytokine, medicine.medical_treatment, Population, education.field_of_study, education, business.industry, business, Internal medicine
Funded by
NIH| CD-73 adenosine signaling in the central nervous system in disease and health
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01NS063011-05
  • Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
,
NIH| Brain endothelial cell function under adenosine receptor signaling directive
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3R01NS078018-02S1
  • Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
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Thies, W, Bleiler, L. 2013 Alzheimer's disease facts and figures. Alzheimers Dement. 2013; 9: 208-45 [OpenAIRE] [PubMed] [DOI]

Lok, K, Zhao, H, Shen, H, Wang, Z, Gao, X, Zhao, W. Characterization of the APP/PS1 mouse model of Alzheimer's disease in senescence accelerated background. Neurosci Lett. 2013; 557, Part B: 84-9 [OpenAIRE] [PubMed] [DOI]

Lalonde, R, Fukuchi, K, Strazielle, C. APP transgenic mice for modelling behavioral and psychological symptoms of dementia (BPSD). Neurosci Biobehav Rev. 2012; 36: 1357-75 [OpenAIRE] [PubMed] [DOI]

Saura, CA, Servian-Morilla, E, Scholl, FG. Presenilin/gamma-secretase regulates neurexin processing at synapses. PLoS One. 2011; 6: e19430 [OpenAIRE] [PubMed] [DOI]

Koedam, EL, Lauffer, V, van der Vlies, AE, van der Flier, WM, Scheltens, P, Pijnenburg, YA. Early-versus late-onset Alzheimer's disease: more than age alone. J Alzheimers Dis. 2010; 19: 1401-8 [PubMed]

7.Moreno-Grau S, Barneda B, Carriba P, Marin J, Sotolongo-Grau O, Hernandez I, et al. Evaluation of candidate genes related to neuronal apoptosis in late-onset Alzheimer's disease. J Alzheimers Dis. 2015;45(2):621-9.

Benilova, I, Karran, E, De Strooper, B. The toxic Abeta oligomer and Alzheimer's disease: an emperor in need of clothes. Nat Neurosci. 2012; 15: 349-57 [OpenAIRE] [PubMed] [DOI]

Suh, J, Choi, SH, Romano, DM, Gannon, MA, Lesinski, AN, Kim, DY. ADAM10 missense mutations potentiate beta-amyloid accumulation by impairing prodomain chaperone function. Neuron. 2013; 80: 385-401 [OpenAIRE] [PubMed] [DOI]

Iba, M, Guo, JL, McBride, JD, Zhang, B, Trojanowski, JQ, Lee, VM. Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy. J Neurosci. 2013; 33: 1024-37 [OpenAIRE] [PubMed] [DOI]

Roberson, ED, Scearce-Levie, K, Palop, JJ, Yan, F, Cheng, IH, Wu, T. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science. 2007; 316: 750-4 [OpenAIRE] [PubMed] [DOI]

Ghareeb, DA, Hafez, HS, Hussien, HM, Kabapy, NF. Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction. Metab Brain Dis. 2011; 26: 253-67 [OpenAIRE] [PubMed] [DOI]

13.Tojima H, Kakizaki S, Kosone T, Horiguchi N, Yamazaki Y, Sato K, et al. Hepatocyte growth factor overexpression ameliorates liver inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis. Hepatol Int. 2011;6(3):620-30.

Daugherity, EK, Balmus, G, Al Saei, A, Moore, ES, Abi Abdallah, D, Rogers, AB. The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease. Cell Cycle. 2012; 11: 1918-28 [OpenAIRE] [PubMed] [DOI]

Zeb, I, Katz, R, Nasir, K, Ding, J, Rezaeian, P, Budoff, MJ. Relation of nonalcoholic fatty liver disease to the metabolic syndrome: the Multi-Ethnic Study of Atherosclerosis. J Cardiovasc Comput Tomogr. 2013; 7: 311-8 [OpenAIRE] [PubMed] [DOI]

55 references, page 1 of 4
Abstract
Background Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease afflicting about one third of the world’s population and 30 % of the US population. It is induced by consumption of high-lipid diets and is characterized by liver inflammation and subsequent liver pathology. Obesity and consumption of a high-fat diet are known to increase the risk of Alzheimer’s disease (AD). Here, we investigated NAFLD-induced liver inflammation in the pathogenesis of AD. Methods WT and APP-Tg mice were fed with a standard diet (SD) or a high-fat diet (HFD) for 2, 5 months, or 1 year to induce NAFLD. Another set of APP-Tg mice were removed from HFD after 2 months an...
Subjects
free text keywords: Immunology, Cellular and Molecular Neuroscience, Neurology, Research, Alzheimer’s disease, Apolipoprotein E, High-fat diet, Non-alcoholic fatty liver disease, Standard diet, General Neuroscience, Alcoholic fatty liver, Endocrinology, medicine.medical_specialty, medicine, Chronic liver disease, medicine.disease, Pathogenesis, Fatty liver, Inflammation, medicine.symptom, Cytokine, medicine.medical_treatment, Population, education.field_of_study, education, business.industry, business, Internal medicine
Funded by
NIH| CD-73 adenosine signaling in the central nervous system in disease and health
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01NS063011-05
  • Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
,
NIH| Brain endothelial cell function under adenosine receptor signaling directive
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3R01NS078018-02S1
  • Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
55 references, page 1 of 4

Serrano-Pozo, A, Frosch, MP, Masliah, E, Hyman, BT. Neuropathological alterations in Alzheimer disease. Cold Spring Harb Perspect Med. 2011; 1: a006189 [OpenAIRE] [PubMed] [DOI]

Thies, W, Bleiler, L. 2013 Alzheimer's disease facts and figures. Alzheimers Dement. 2013; 9: 208-45 [OpenAIRE] [PubMed] [DOI]

Lok, K, Zhao, H, Shen, H, Wang, Z, Gao, X, Zhao, W. Characterization of the APP/PS1 mouse model of Alzheimer's disease in senescence accelerated background. Neurosci Lett. 2013; 557, Part B: 84-9 [OpenAIRE] [PubMed] [DOI]

Lalonde, R, Fukuchi, K, Strazielle, C. APP transgenic mice for modelling behavioral and psychological symptoms of dementia (BPSD). Neurosci Biobehav Rev. 2012; 36: 1357-75 [OpenAIRE] [PubMed] [DOI]

Saura, CA, Servian-Morilla, E, Scholl, FG. Presenilin/gamma-secretase regulates neurexin processing at synapses. PLoS One. 2011; 6: e19430 [OpenAIRE] [PubMed] [DOI]

Koedam, EL, Lauffer, V, van der Vlies, AE, van der Flier, WM, Scheltens, P, Pijnenburg, YA. Early-versus late-onset Alzheimer's disease: more than age alone. J Alzheimers Dis. 2010; 19: 1401-8 [PubMed]

7.Moreno-Grau S, Barneda B, Carriba P, Marin J, Sotolongo-Grau O, Hernandez I, et al. Evaluation of candidate genes related to neuronal apoptosis in late-onset Alzheimer's disease. J Alzheimers Dis. 2015;45(2):621-9.

Benilova, I, Karran, E, De Strooper, B. The toxic Abeta oligomer and Alzheimer's disease: an emperor in need of clothes. Nat Neurosci. 2012; 15: 349-57 [OpenAIRE] [PubMed] [DOI]

Suh, J, Choi, SH, Romano, DM, Gannon, MA, Lesinski, AN, Kim, DY. ADAM10 missense mutations potentiate beta-amyloid accumulation by impairing prodomain chaperone function. Neuron. 2013; 80: 385-401 [OpenAIRE] [PubMed] [DOI]

Iba, M, Guo, JL, McBride, JD, Zhang, B, Trojanowski, JQ, Lee, VM. Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy. J Neurosci. 2013; 33: 1024-37 [OpenAIRE] [PubMed] [DOI]

Roberson, ED, Scearce-Levie, K, Palop, JJ, Yan, F, Cheng, IH, Wu, T. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science. 2007; 316: 750-4 [OpenAIRE] [PubMed] [DOI]

Ghareeb, DA, Hafez, HS, Hussien, HM, Kabapy, NF. Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction. Metab Brain Dis. 2011; 26: 253-67 [OpenAIRE] [PubMed] [DOI]

13.Tojima H, Kakizaki S, Kosone T, Horiguchi N, Yamazaki Y, Sato K, et al. Hepatocyte growth factor overexpression ameliorates liver inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis. Hepatol Int. 2011;6(3):620-30.

Daugherity, EK, Balmus, G, Al Saei, A, Moore, ES, Abi Abdallah, D, Rogers, AB. The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease. Cell Cycle. 2012; 11: 1918-28 [OpenAIRE] [PubMed] [DOI]

Zeb, I, Katz, R, Nasir, K, Ding, J, Rezaeian, P, Budoff, MJ. Relation of nonalcoholic fatty liver disease to the metabolic syndrome: the Multi-Ethnic Study of Atherosclerosis. J Cardiovasc Comput Tomogr. 2013; 7: 311-8 [OpenAIRE] [PubMed] [DOI]

55 references, page 1 of 4
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publication . Article . 2016

Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Do-Geun Kim; Antje Krenz; Leon E. Toussaint; Kirk J. Maurer; Sudie-Ann Robinson; Angela Yan; Luisa Torres; Margaret S. Bynoe;