publication . Article . Other literature type . 2003

Dynamics of Gray Matter Loss in Alzheimer's Disease

Thompson, P. M.; Hayashi, K. M.; Zubicaray, G.; Andrew Janke; Rose, S. E.; Semple, J.; Herman, D.; Hong, M. S.; Dittmer, S. S.; Doddrell, D. M.; ...
Open Access English
  • Published: 01 Feb 2003
  • Publisher: eScholarship, University of California
  • Country: Algeria
Abstract
We detected and mapped a dynamically spreading wave of gray matter loss in the brains of patients with Alzheimer's disease (AD). The loss pattern was visualized in four dimensions as it spread over time from temporal and limbic cortices into frontal and occipital brain regions, sparing sensorimotor cortices. The shifting deficits were asymmetric (left hemisphere > right hemisphere) and correlated with progressively declining cognitive status (p< 0.0006). Novel brain mapping methods allowed us to visualize dynamic patterns of atrophy in 52 high-resolution magnetic resonance image scans of 12 patients with AD (age 68.4 ± 1.9 years) and 14 elderly matched controls ...
Subjects
free text keywords: Alzheimer's disease, aging, dementia, magnetic resonance imaging, brain mapping, imaging, longitudinal, cortex, Article, General Neuroscience
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