publication . Article . 2017

Outcome-wide Epidemiology.

Tyler J. VanderWeele;
Open Access
  • Published: 01 Apr 2017 Journal: Epidemiology, volume 28, pages 399-402 (issn: 1044-3983, Copyright policy)
  • Publisher: Ovid Technologies (Wolters Kluwer Health)
  • Country: United States
Abstract
The author proposes that epidemiologic studies should more often assess the associations of a single exposure with multiple outcomes simultaneously. Such “outcome-wide epidemiology” will be especially important for exposures that may be beneficial for some outcomes but harmful for others. Outcome-wide epidemiology may also be helpful in prioritizing public health recommendations. Methodologically, the conduct of outcome-wide epidemiology will generally be more straightforward than recent proposals for exposure-wide epidemiologic studies, in which the associations between a single outcome and many exposures are assessed simultaneously. Such exposure-wide studies ...
Subjects
free text keywords: Epidemiology, Methods, Single exposure, medicine.medical_specialty, medicine, Environmental health, business.industry, business
Funded by
NIH| Theory and methods for sufficient cause interactions
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01ES017876-02
  • Funding stream: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
31 references, page 1 of 3

1.Ioannidis JP Exposure-wide epidemiology: revisiting Bradford Hill.Stat Med. 2016;35:1749 1762.26646432 [PubMed]

2.Hunter DJ Lessons from genome-wide association studies for epidemiology.Epidemiology. 2012;23:363 367.22475827 [PubMed]

3.Welter D MacArthur J Morales J The NHGRI GWAS Catalog, a curated resource of SNP-trait associations.Nucleic Acids Res. 2014;42(Database issue):D1001 D1006.24316577 [OpenAIRE] [PubMed]

4.GWAS Catalog. Available at: https://www.ebi.ac.uk/gwas/ Accessed 1 July 2016.

5.MacKinnon D Statistical Mediation Analysis. 2008 New York, NY: Routledge.

6.VanderWeele TJ Explanation in Causal Inference: Methods for Mediation and Interaction. 2015 New York, NY: Oxford University Press.

7.Hernán MA Hernández-Díaz S Robins JM A structural approach to selection bias.Epidemiology. 2004;15:615 625.15308962 [PubMed]

8.Cole SR Platt RW Schisterman EF Illustrating bias due to conditioning on a collider.Int J Epidemiol. 2010;39:417 420.19926667 [OpenAIRE] [PubMed]

9.Fryer R Orley A David C Racial inequality in the 21st century: the declining significance of discrimination.In: Handbook of Labor Economics, 2011:vol. 4, part B Amsterdam, Netherlands: Elsevier; 855 971.

10.Neal DA Johnson WR The role of premarket factors in black-white wage diff erences.J Polit Econ. 104: 869 895.

11.Yerushalmy J The relationship of parents’ cigarette smoking to outcome of pregnancy–implications as to the problem of inferring causation from observed associations.Am J Epidemiol. 1971;93:443 456.5562717 [PubMed]

12.Wilcox AJ Birth weight and perinatal mortality: the effect of maternal smoking.Am J Epidemiol. 1993;137:1098 1104.8317439 [PubMed]

13.Hernández-Díaz S Schisterman EF Hernán MA The birth weight “paradox” uncovered?Am J Epidemiol. 2006;164:1115 1120.16931543 [PubMed]

14.VanderWeele TJ Mumford SL Schisterman EF Conditioning on intermediates in perinatal epidemiology.Epidemiology. 2012;23:1 9.22157298 [OpenAIRE] [PubMed]

15.Hernán MA Counterpoint: epidemiology to guide decision-making: moving away from practice-free research.Am J Epidemiol. 2015;182:834 839.26507306 [OpenAIRE] [PubMed]

31 references, page 1 of 3
Abstract
The author proposes that epidemiologic studies should more often assess the associations of a single exposure with multiple outcomes simultaneously. Such “outcome-wide epidemiology” will be especially important for exposures that may be beneficial for some outcomes but harmful for others. Outcome-wide epidemiology may also be helpful in prioritizing public health recommendations. Methodologically, the conduct of outcome-wide epidemiology will generally be more straightforward than recent proposals for exposure-wide epidemiologic studies, in which the associations between a single outcome and many exposures are assessed simultaneously. Such exposure-wide studies ...
Subjects
free text keywords: Epidemiology, Methods, Single exposure, medicine.medical_specialty, medicine, Environmental health, business.industry, business
Funded by
NIH| Theory and methods for sufficient cause interactions
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01ES017876-02
  • Funding stream: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
31 references, page 1 of 3

1.Ioannidis JP Exposure-wide epidemiology: revisiting Bradford Hill.Stat Med. 2016;35:1749 1762.26646432 [PubMed]

2.Hunter DJ Lessons from genome-wide association studies for epidemiology.Epidemiology. 2012;23:363 367.22475827 [PubMed]

3.Welter D MacArthur J Morales J The NHGRI GWAS Catalog, a curated resource of SNP-trait associations.Nucleic Acids Res. 2014;42(Database issue):D1001 D1006.24316577 [OpenAIRE] [PubMed]

4.GWAS Catalog. Available at: https://www.ebi.ac.uk/gwas/ Accessed 1 July 2016.

5.MacKinnon D Statistical Mediation Analysis. 2008 New York, NY: Routledge.

6.VanderWeele TJ Explanation in Causal Inference: Methods for Mediation and Interaction. 2015 New York, NY: Oxford University Press.

7.Hernán MA Hernández-Díaz S Robins JM A structural approach to selection bias.Epidemiology. 2004;15:615 625.15308962 [PubMed]

8.Cole SR Platt RW Schisterman EF Illustrating bias due to conditioning on a collider.Int J Epidemiol. 2010;39:417 420.19926667 [OpenAIRE] [PubMed]

9.Fryer R Orley A David C Racial inequality in the 21st century: the declining significance of discrimination.In: Handbook of Labor Economics, 2011:vol. 4, part B Amsterdam, Netherlands: Elsevier; 855 971.

10.Neal DA Johnson WR The role of premarket factors in black-white wage diff erences.J Polit Econ. 104: 869 895.

11.Yerushalmy J The relationship of parents’ cigarette smoking to outcome of pregnancy–implications as to the problem of inferring causation from observed associations.Am J Epidemiol. 1971;93:443 456.5562717 [PubMed]

12.Wilcox AJ Birth weight and perinatal mortality: the effect of maternal smoking.Am J Epidemiol. 1993;137:1098 1104.8317439 [PubMed]

13.Hernández-Díaz S Schisterman EF Hernán MA The birth weight “paradox” uncovered?Am J Epidemiol. 2006;164:1115 1120.16931543 [PubMed]

14.VanderWeele TJ Mumford SL Schisterman EF Conditioning on intermediates in perinatal epidemiology.Epidemiology. 2012;23:1 9.22157298 [OpenAIRE] [PubMed]

15.Hernán MA Counterpoint: epidemiology to guide decision-making: moving away from practice-free research.Am J Epidemiol. 2015;182:834 839.26507306 [OpenAIRE] [PubMed]

31 references, page 1 of 3
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