publication . Other literature type . Article . 2011

The relationship between relative solvent accessibility and evolutionary rate in protein evolution.

Ramsey, Duncan C.; Scherrer, Michael P.; Zhou, Tong; Wilke, Claus O.;
Open Access English
  • Published: 01 Jun 2011
  • Publisher: Genetics Society of America
Abstract
Recent work with Saccharomyces cerevisiae shows a linear relationship between the evolutionary rate of sites and the relative solvent accessibility (RSA) of the corresponding residues in the folded protein. Here, we aim to develop a mathematical model that can reproduce this linear relationship. We first demonstrate that two models that both seem reasonable choices (a simple model in which selection strength correlates with RSA and a more complex model based on RSA-dependent amino acid distributions) fail to reproduce the observed relationship. We then develop a model on the basis of observed site-specific amino acid distributions and show that this model behave...
Subjects
free text keywords: Investigations, Genetics, Amino acid, chemistry.chemical_classification, chemistry, Saccharomyces cerevisiae, biology.organism_classification, biology, Protein evolution, Solvent accessibility, Saccharomyces cerevisiae Proteins, Biochemistry
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Other literature type . 2011
Genetics
Article
Provider: UnpayWall
http://dx.doi.org/10.1534/gene...
Other literature type . 2011
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publication . Other literature type . Article . 2011

The relationship between relative solvent accessibility and evolutionary rate in protein evolution.

Ramsey, Duncan C.; Scherrer, Michael P.; Zhou, Tong; Wilke, Claus O.;