publication . Other literature type . Article . 2019

Transferrin and transferrin receptors update.

Hiroshi Kawabata;
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  • Published: 01 Mar 2019
  • Publisher: Elsevier BV
Abstract
Abstract In vertebrates, transferrin (Tf) safely delivers iron through circulation to cells. Tf-bound iron is incorporated through Tf receptor (TfR) 1-mediated endocytosis. TfR1 can mediate cellular uptake of both Tf and H-ferritin, an iron storage protein. New World arenaviruses, which cause hemorrhagic fever, and Plasmodium vivax use TfR1 for entry into host cells. Human TfR2, another receptor for Tf, is predominantly expressed in hepatocytes and erythroid precursors, and holo-Tf dramatically upregulates its expression. TfR2 forms a complex with hemochromatosis protein, HFE, and serves as a component of the iron sensing machinery in hepatocytes. Defects in TfR...
Subjects
free text keywords: Physiology (medical), Biochemistry
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