publication . Article . Other literature type . 1998

Comparison of Population-Averaged and Subject-Specific Approaches for Analyzing Repeated Binary Outcomes

Hu, F. B.; Goldberg, J.; Hedeker, D.; Brian Flay; Pentz, M. A.;
Open Access
  • Published: 01 Apr 1998 Journal: American Journal of Epidemiology, volume 147, pages 694-703 (issn: 0002-9262, eissn: 1476-6256, Copyright policy)
  • Publisher: Oxford University Press (OUP)
: Several approaches have been proposed to model binary outcomes that arise from longitudinal studies. Most of the approaches can be grouped into two classes: the population-averaged and subject-specific approaches. The generalized estimating equations (GEE) method is commonly used to estimate population-averaged effects, while random-effects logistic models can be used to estimate subject-specific effects. However, it is not clear to many epidemiologists how these two methods relate to one another or how these methods relate to more traditional stratified analysis and standard logistic models. The authors address these issues in the context of a longitudinal sm...
free text keywords: Epidemiology
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