publication . Article . Other literature type . 2015

BALB/c and C57BL/6 Mice Differ in Polyreactive IgA Abundance, which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity

Sahar El Aidy;
Open Access English
  • Published: 01 Sep 2015 Journal: Immunity, issue 3, pages 527-540 (issn: 10747613, Copyright policy)
  • Publisher: Elsevier Inc.
SUMMARY The interrelationship between IgAs and microbiota diversity is still unclear. Here we show that BALB/c mice had higher abundance and diversity of IgAs than C57BL/6 mice and that this correlated with increased microbiota diversity. We show that polyreactive IgAs mediated the entrance of non-invasive bacteria to Peyer’s patches, independently of CX3CR1 + phagocytes. This allowed the induction of bacteria-specific IgA and the establishment of a positive feedback loop of IgA production. Cohousing of mice or fecal transplantation had little or no influence on IgA production and had only partial impact on microbiota composition. Germ-free BALB/c, but not C57BL...
Medical Subject Headings: human activities
free text keywords: Immunology, Immunology and Allergy, Infectious Diseases, Biology, Microbiology, Immunoglobulin A, biology.protein, Genetic variation, C57BL/6, biology.organism_classification, BALB/c, Colonization, Fecal bacteriotherapy, Genetic predisposition, Antigen
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