publication . Article . Other literature type . 1994

Adhesion forces between individual ligand-receptor pairs

Ernst-Ludwig Florin; Vincent T. Moy; Hermann E. Gaub;
Open Access
  • Published: 15 Apr 1994 Journal: Science, volume 264, pages 415-417 (issn: 0036-8075, eissn: 1095-9203, Copyright policy)
  • Publisher: American Association for the Advancement of Science (AAAS)
The adhesion force between the tip of an atomic force microscope cantilever derivatized with avidin and agarose beads functionalized with biotin, desthiobiotin, or iminobiotin was measured. Under conditions that allowed only a limited number of molecular pairs to interact, the force required to separate tip and bead was found to be quantized in integer multiples of 160 +/- 20 piconewtons for biotin and 85 +/- 15 piconewtons for iminobiotin. The measured force quanta are interpreted as the unbinding forces of individual molecular pairs.
free text keywords: Multidisciplinary, Biotin, chemistry.chemical_compound, chemistry, Cantilever, Ligand (biochemistry), Force spectroscopy, Avidin, biology.protein, biology, Agarose, Ligand, Adhesion, Stereochemistry, Biophysics
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