publication . Article . Other literature type . 2008

Discrimination between Alzheimer Disease, Mild Cognitive Impairment, and Normal Aging by Using Automated Segmentation of the Hippocampus

Béatrice Desgranges; Bruno Dubois; Marie Chupin; Francis Eustache; Gaël Chételat; Line Garnero; Olivier Colliot; Habib Benali; Benoît Magnin; Stéphane Lehéricy;
Open Access English
  • Published: 01 Jul 2008
  • Publisher: HAL CCSD
  • Country: France
International audience; PURPOSE: To prospectively evaluate the accuracy of automated hippocampal volumetry to help distinguish between patients with Alzheimer disease (AD), patients with mild cognitive impairment (MCI), and elderly controls, by using established criteria for patients with AD and MCI as the reference standard. MATERIALS AND METHODS: The regional ethics committee approved the study and written informed consent was obtained from all participants. The study included 25 patients with AD (11 men, 14 women; mean age +/- standard deviation [SD], 73 years +/- 6; Mini-Mental State Examination (MMSE) score, 24.4 +/- 2.7), 24 patients with amnestic MCI (10 ...
free text keywords: Alzheimer's disease, MCI, hippocampus, magnetic resonance imaging, image processing, MESH: Aged, MESH: Aging, MESH: Image Enhancement, MESH: Image Interpretation, Computer-Assisted, MESH: Magnetic Resonance Imaging, MESH: Male, MESH: Middle Aged, MESH: Pattern Recognition, Automated, MESH: Reproducibility of Results, MESH: Sensitivity and Specificity, MESH: Algorithms, MESH: Alzheimer Disease, MESH: Artificial Intelligence, MESH: Cognition Disorders, MESH: Diagnosis, Differential, MESH: Female, MESH: Hippocampus, MESH: Humans, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Radiology Nuclear Medicine and imaging, Cognitive impairment, Internal medicine, medicine.medical_specialty, medicine, Central nervous system disease, medicine.disease, business.industry, business, Cognitive disorder, Pathology, Degenerative disease, medicine.diagnostic_test, Informed consent
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