publication . Article . Other literature type . 2009

RanBPM Has Proapoptotic Activities That Regulate Cell Death Pathways in Response to DNA Damage

Atabakhsh, E.; Bryce, D. M.; Lefebvre, K. J.; Schild-Poulter, C.;
Open Access
  • Published: 18 Dec 2009 Journal: Molecular Cancer Research, volume 7, pages 1,962-1,972 (issn: 1541-7786, eissn: 1557-3125, Copyright policy)
  • Publisher: American Association for Cancer Research (AACR)
Abstract
Ran-binding protein M (RanBPM) is a nucleocytoplasmic protein previously implicated in various signaling pathways, but whose function remains enigmatic. Here, we provide evidence that RanBPM functions as an activator of apoptotic pathways induced by DNA damage. First, transient expression of RanBPM in HeLa cells induced cell death through caspase activation, and in the long-term, forced expression of RanBPM impaired cell viability. RanBPM COOH-terminal domain stimulated the ability of RanBPM to induce caspase activation, whereas this activity was negatively regulated by the central SPRY domain. Second, small interfering RNA-directed knockdown of RanBPM prevented...
Subjects
free text keywords: Cancer Research, Oncology, Molecular Biology, Signal transduction, Downregulation and upregulation, Apoptosis, Programmed cell death, Cell biology, Bcl-2-associated X protein, biology.protein, biology, Nuclear protein, DNA damage, Caspase
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