publication . Article . Other literature type . 2007

Amyloid Deposition Begins in the Striatum of Presenilin-1 Mutation Carriers from Two Unrelated Pedigrees

Howard Aizenstein;
  • Published: 06 Jun 2007
  • Publisher: Society for Neuroscience
Abstract
The amyloid cascade hypothesis suggests that the aggregation and deposition of amyloid-β protein is an initiating event in Alzheimer9s disease (AD). Using amyloid imaging technology, such as the positron emission tomography (PET) agent Pittsburgh compound-B (PiB), it is possible to explore the natural history of preclinical amyloid deposition in people at high risk for AD. With this goal in mind, asymptomatic ( n = 5) and symptomatic ( n = 5) carriers of presenilin-1 (PS1) mutations (C410Y or A426P) that lead to early-onset AD and noncarrier controls from both kindreds ( n = 2) were studied with PiB–PET imaging and compared with sporadic AD subjects ( n = 12) an...
Subjects
Medical Subject Headings: mental disorders
free text keywords: Biology, Amyloid, Striatum, Asymptomatic, medicine.symptom, medicine, Presenilin, Alzheimer's disease, medicine.disease, Pittsburgh compound B, chemistry.chemical_compound, chemistry, Population, education.field_of_study, education, Pathology, medicine.medical_specialty, Mutation, medicine.disease_cause, Article
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publication . Article . Other literature type . 2007

Amyloid Deposition Begins in the Striatum of Presenilin-1 Mutation Carriers from Two Unrelated Pedigrees

Howard Aizenstein;