publication . Article . Other literature type . 2003

Fine-Scale Mapping of Disease Genes with Multiple Mutations via Spatial Clustering Techniques

John Molitor; Paul Marjoram; Duncan Thomas;
Open Access
  • Published: 01 Dec 2003 Journal: The American Journal of Human Genetics, volume 73, issue 6, pages 1,368-1,384 (issn: 0002-9297, Copyright policy)
  • Publisher: Elsevier BV
We present a method to perform fine mapping by placing haplotypes into clusters on the basis of risk. Each cluster has a haplotype “center.” Cluster allocation is defined according to haplotype centers, with each haplotype assigned to the cluster with the “closest” center. The closeness of two haplotypes is determined by a similarity metric that measures the length of the shared segment around the location of a putative functional mutation for the particular cluster. Our method allows for missing marker information but still estimates the risks of complete haplotypes without resorting to a one-marker-at-a-time analysis. The dimensionality issues that can occur i...
free text keywords: Genetics(clinical), Genetics, Articles, Gene mapping, Haplotype estimation, Haplotype, Bayes' theorem, Closeness, Biology, Curse of dimensionality, Cluster analysis, Markov chain
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