publication . Article . Other literature type . 2007

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.

Haass, Christian; Selkoe, Dennis J.;
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  • Published: 01 Feb 2007 Journal: Nature Reviews Molecular Cell Biology, volume 8, pages 101-112 (issn: 1471-0072, eissn: 1471-0080, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
Certain neurodegenerative disorders are characterized by the progressive accumulation of insoluble deposits of misfolded proteins. Amyloid β-protein (Aβ) oligomers affect synaptic structure and plasticity in Alzheimer's disease, and recent findings in other neurodegenerative diseases indicate that a broadly similar process of neuronal dysfunction is induced by diffusible oligomers of misfolded proteins.
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