publication . Other literature type . Article . 2010

The behaviour of neural stem cells on polyhydroxyalkanoate nanofiber scaffolds.

Si-Wu Peng; Guo Fang; Jian-Feng Xiao; Xian-Yi Xu; Guo-Qiang Chen; Xiao-Tao Li; Kevin C. Chen; Chao Liu;
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  • Published: 01 May 2010
  • Publisher: Elsevier BV
Abstract
Polyhydroxyalkanoates (PHA) have demonstrated their potentials as medical implant biomaterials. Neural stem cells (NSCs) grown on/in PHA scaffolds may be useful for repairing central nervous system (CNS) injury. To investigate this possibility, nanofiber matrices (scaffolds) prepared from several PHA via a novel phase separation process were studied to mimic natural extracellular matrix (ECM), and rat-derived NSCs grown in the PHA matrices were characterized regarding their in vitro differentiation behaviors. All three PHA materials including poly(3-hydroxybutyrate) (PHB), copolymer of 3-hydroxybutyrate and 4-hydroxybutyrate (P3HB4HB), and copolymer of 3-hydroxy...
Subjects
Medical Subject Headings: nervous system
free text keywords: Biophysics, Mechanics of Materials, Bioengineering, Biomaterials, Ceramics and Composites, Phase separation process, Synaptogenesis, Nanofiber, In vitro, Neural stem cell, Cell biology, Biomedical engineering, Extracellular matrix, Materials science, Polyhydroxyalkanoates, Scaffold
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