publication . Other literature type . Article . 2006

[11C]PIB in a nondemented population Potential antecedent marker of Alzheimer disease

M. A. Mintun; G. N. LaRossa; Y. I. Sheline; C. S. Dence; S. Y. Lee; R. H. Mach; W. E. Klunk; C. A. Mathis; S. T. DeKosky; J. C. Morris;
  • Published: 07 Aug 2006
  • Publisher: Ovid Technologies (Wolters Kluwer Health)
Background: Beta-amyloid (Aβ) plaques are the hallmark of Alzheimer disease (AD). A PET imaging tracer that binds to Aβ plaques in vivo, N-methyl-[11C]2-(4′-methylaminophenyl)-6-hydroxybenzothiazole (or [11C]PIB for “Pittsburgh Compound-B”), has significantly higher binding in subjects diagnosed with dementia of the Alzheimer type (DAT) compared to nondemented controls. The authors used this imaging technique to investigate whether abnormal binding occurs in clinically normal individuals, prior to the development of cognitive changes. Methods: Forty-one nondemented subjects (age range 20 to 86 years) and 10 patients with DAT (age range 66 to 86 years) underwent ...
free text keywords: Dementia, medicine.disease, medicine, Cerebellar cortex, Pittsburgh compound B, chemistry.chemical_compound, chemistry, Degenerative disease, Pathology, medicine.medical_specialty, business.industry, business, Alzheimer's disease, Florbetaben, Precuneus, medicine.anatomical_structure, Population, education.field_of_study, education
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