publication . Article . 2007

An investigation of the effects of lipid-lowering medications: Genome-wide linkage analysis of lipids in the HyperGEN study

Treva Rice; R. Curtis Ellison; Hilary Coon;
Open Access
  • Published: 01 Sep 2007 Journal: BMC Genetics, volume 8 (eissn: 1471-2156, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
<p>Abstract</p> <p>Background</p> <p>Use of anti-hyperlipidemic medications compromises genetic analysis because of altered lipid profiles. We propose an empirical method to adjust lipid levels for medication effects so that the adjusted lipid values substitute the unmedicated lipid values in the genetic analysis.</p> <p>Results</p> <p>Published clinical trials were reviewed for HMG-CoA reductase inhibitors and fibric acid derivatives as mono-drug therapy. HMG-CoA reductase inhibitors showed similar effects in African Americans (AA) and non-African Americans (non-AA) for lowering total cholesterol (TC, -50.7 mg/dl), LDL cholesterol (LDL-C, -48.1 mg/dl), and trig...
Subjects
Medical Subject Headings: lipids (amino acids, peptides, and proteins)
free text keywords: Genetics(clinical), Genetics, Research Article, QH426-470
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