publication . Article . Other literature type . 2002

The Pattern of Amino Acid Replacements in α/β-Barrels

Dean, Antony M.; Neuhauser, Claudia; Grenier, Elise; Golding, G. Brian;
Open Access
  • Published: 01 Nov 2002 Journal: Molecular Biology and Evolution, volume 19, pages 1,846-1,864 (issn: 0737-4038, eissn: 1537-1719, Copyright policy)
  • Publisher: Oxford University Press (OUP)
Abstract
The determinants of site-to-site variability in the rate of amino acid replacement in α/β-barrel enzyme structures are investigated. Of 125 available α/β-barrel structures, only 25 meet a variety of phylogenetic and statistical criteria necessary to ensure sufficient data for reliable analysis. These 25 enzyme structures (from a wide variety of taxa with diverse lifestyles in diverse habitats) differ greatly in size, number, and topology of domains in addition to the α/β-barrel, quaternary structure, metabolic role, reaction catalyzed, presence of prosthetic groups, regulatory mechanisms, use of cofactors, and catalytic mechanisms. Yet, with the exception of rib...
Subjects
free text keywords: Stereochemistry, Protein secondary structure, Genetics, Phylogenetic tree, Amino acid, chemistry.chemical_classification, chemistry, Conformational isomerism, Protein quaternary structure, Enzyme, Active site, biology.protein, biology, Peptide bond, Biochemistry
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publication . Article . Other literature type . 2002

The Pattern of Amino Acid Replacements in α/β-Barrels

Dean, Antony M.; Neuhauser, Claudia; Grenier, Elise; Golding, G. Brian;