publication . Article . 2008

Identification and characterization of novel human tissue-specific RFX transcription factors.

Aftab, Syed; Semenec, Lucie; Chu, Jeffrey; Chen, Nansheng;
Open Access English
  • Published: 01 Aug 2008 Journal: BMC Evolutionary Biology, volume 8, pages 226-226 (eissn: 1471-2148, Copyright policy)
  • Publisher: BioMed Central
  • Country: Canada
Abstract
<p>Abstract</p> <p>Background</p> <p>Five regulatory factor X (RFX) transcription factors (TFs)–RFX1-5–have been previously characterized in the human genome, which have been demonstrated to be critical for development and are associated with an expanding list of serious human disease conditions including major histocompatibility (MHC) class II deficiency and ciliaophathies.</p> <p>Results</p> <p>In this study, we have identified two additional RFX genes–RFX6 and RFX7–in the current human genome sequences. Both RFX6 and RFX7 are demonstrated to be winged-helix TFs and have well conserved RFX DNA binding domains (DBDs), which are also found in winged-helix TFs RF...
Subjects
free text keywords: Research Article, Evolution, QH359-425, Ecology, Evolution, Behavior and Systematics, DNA-binding protein, Histocompatibility, Biology, Bare lymphocyte syndrome, medicine.disease, medicine, Genetics, Regulatory Factor X1, Human genome, RFX6, Major histocompatibility complex, biology.protein, Transcription factor
Funded by
NSERC
Project
  • Funder: Natural Sciences and Engineering Research Council of Canada (NSERC)
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publication . Article . 2008

Identification and characterization of novel human tissue-specific RFX transcription factors.

Aftab, Syed; Semenec, Lucie; Chu, Jeffrey; Chen, Nansheng;