publication . Article . 2008

Identification and characterization of novel human tissue-specific RFX transcription factors.

Aftab, Syed; Semenec, Lucie; Chu, Jeffrey; Chen, Nansheng;
Open Access English
  • Published: 01 Aug 2008 Journal: BMC Evolutionary Biology, volume 8, pages 226-226 (eissn: 1471-2148, Copyright policy)
  • Publisher: BioMed Central
  • Country: Canada
<p>Abstract</p> <p>Background</p> <p>Five regulatory factor X (RFX) transcription factors (TFs)–RFX1-5–have been previously characterized in the human genome, which have been demonstrated to be critical for development and are associated with an expanding list of serious human disease conditions including major histocompatibility (MHC) class II deficiency and ciliaophathies.</p> <p>Results</p> <p>In this study, we have identified two additional RFX genes–RFX6 and RFX7–in the current human genome sequences. Both RFX6 and RFX7 are demonstrated to be winged-helix TFs and have well conserved RFX DNA binding domains (DBDs), which are also found in winged-helix TFs RF...
free text keywords: Research Article, Evolution, QH359-425, Ecology, Evolution, Behavior and Systematics, DNA-binding protein, Histocompatibility, Biology, Bare lymphocyte syndrome, medicine.disease, medicine, Genetics, Regulatory Factor X1, Human genome, RFX6, Major histocompatibility complex, biology.protein, Transcription factor
Funded by
  • Funder: Natural Sciences and Engineering Research Council of Canada (NSERC)
46 references, page 1 of 4

Cell 1988, 53:897-906.

Dorn A, Durand B, Marfing C, Le Meur M, Benoist C, Mathis D: Conserved major histocompatibility complex class II boxes-X and Y-are transcriptional control elements and specifically bind nuclear proteins. Proc Natl Acad Sci USA 1987, 84:6249-6253. [OpenAIRE]

Sherman PA, Basta PV, Ting JP: Upstream DNA sequences required for tissue-specific expression of the HLA-DR alpha gene. Proc Natl Acad Sci U S A 1987, 84(12):4254-4258. [OpenAIRE]

Kara CJ, Glimcher LH: Regulation of MHC class II gene transcription. Curr Opin Immunol 1991, 3:16-21. [OpenAIRE]

Reith W, Barras E, Satola S, Kobr M, Reinhart D, Sanchez CH, Mach B: Cloning of the major histocompatibility complex class II promoter binding protein affected in a hereditary defect in class II gene regulation. Proc Natl Acad Sci U S A 1989, 86(11):4200-4204. [OpenAIRE]

6. Siegrist CA, Durand B, Emery P, David E, Hearing P, Mach B, Reith W: RFX1 is identical to enhancer factor C and functions as a transactivator of the hepatitis B virus enhancer. Mol Cell Biol 1993, 13:6375-6384.

7. Reith W, Ucla C, Barras E, Gaud A, Durand B, Herrero-Sanchez C, Kobr M, Mach B: RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. Mol Cell Biol 1994, 14:1230-1244. [OpenAIRE]

8. Dotzlaw H, Alkhalaf M, Murphy LC: Characterization of estrogen receptor variant mRNAs from human breast cancers. Mol Endocrinol 1992, 6(5):773-785. [OpenAIRE]

9. Steimle V, Durand B, Barras E, Zufferey M, Hadam MR, Mach B, Reith W: A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome). Genes Dev 1995, 9(9):1021-1032. [OpenAIRE]

10. Huang M, Zhou Z, Elledge SJ: The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell 1998, 94(5):595-605.

11. Wu SY, McLeod M: The sak1+ gene of Schizosaccharomyces pombe encodes an RFX family DNA-binding protein that positively regulates cyclic AMP-dependent protein kinasemediated exit from the mitotic cell cycle. Mol Cell Biol 1995, 15(3):1479-1488.

12. Swoboda P, Adler HT, Thomas JH: The RFX-type transcription factor DAF-19 regulates sensory neuron cilium formation in C. elegans. Mol Cell 2000, 5:411-421.

13. Emery P, Durand B, Mach B, Reith W: RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom. Nucleic Acids Res 1996, 24(5):803-807.

14. Dubruille R, Laurencon A, Vandaele C, Shishido E, Coulon-Bublex M, Swoboda P, Couble P, Kernan M, Durand B: Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation. Development 2002, 129(23):5487-5498.

15. Otsuki K, Hayashi Y, Kato M, Yoshida H, Yamaguchi M: Characterization of dRFX2, a novel RFX family protein in Drosophila. Nucleic Acids Res 2004, 32(18):5636-5648.

46 references, page 1 of 4
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2008

Identification and characterization of novel human tissue-specific RFX transcription factors.

Aftab, Syed; Semenec, Lucie; Chu, Jeffrey; Chen, Nansheng;