publication . Other literature type . Article . 2015

Genetic Case-Control Study for Eight Polymorphisms Associated with Rheumatoid Arthritis

Saad, Mohamed N.; Mabrouk, Mai S.; Eldeib, Ayman M.; Shaker, Olfat G.;
  • Published: 06 Jul 2015
  • Publisher: Public Library of Science (PLoS)
Abstract
Rheumatoid arthritis (RA) is an autoimmune disease which has a significant socio-economic impact. The aim of the current study was to investigate eight candidate RA susceptibility loci to identify the associated variants in Egyptian population. Eight single nucleotide polymorphisms (SNPs) (MTHFR-C677T and A1298C, TGFβ1 T869C, TNFB A252G, and VDR-ApaI, BsmI, FokI, and TaqI) were tested by genotyping patients with RA (n = 105) and unrelated controls (n = 80). Associations were tested using multiplicative, dominant, recessive, and co-dominant models. Also, the linkage disequilibrium (LD) between the VDR SNPs was measured to detect any indirect association. By compa...
Subjects
free text keywords: Medicine, R, Science, Q, Research Article, General Biochemistry, Genetics and Molecular Biology, General Agricultural and Biological Sciences, General Medicine, Methylenetetrahydrofolate reductase, biology.protein, biology, Genetics, TaqI, chemistry.chemical_compound, chemistry, Haplotype, Linkage disequilibrium, Single-nucleotide polymorphism, FokI, business.industry, business, Population, education.field_of_study, education, Allele frequency
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62 references, page 1 of 5

1 Saad MN, Mabrouk MS, Eldeib AM, Shaker OG. Identification of rheumatoid arthritis biomarkers based on single nucleotide polymorphisms and haplotype blocks: a systematic review and meta-analysis. J Adv Res. 2015 10.1016/j.jare.2015.01.008 [OpenAIRE] [DOI]

2 Lewis CM. Genetic association studies: design, analysis and interpretation. Brief Bioinform. 2002;3(2): 146–153. 12139434 [PubMed]

3 Lewis CM, Knight J. Introduction to genetic association studies. Cold Spring Harb Protoc. 2012;2012(3): 297–306. 10.1101/pdb.top068163 22383645 [PubMed] [DOI]

4 The basics of genetic association analysis In: Laird NM, Lange C, editors. The fundamentals of modern statistical genetics: Springer; 2010 pp. 99–108.

5 Rubini M, Padovan M, Baricordi O, Fotinidi M, Govoni M, Trotta F. The c.1298A>C polymorphism in the methylenetetrahydrofolate reductase gene is associated with rheumatoid arthritis susceptibility in Italian patients. Clin Exp Rheumatol. 2008;26(1): 163 18328173 [OpenAIRE] [PubMed]

6 Palomino-Morales R, Gonzalez-Juana tey C, Vazquez-Rodriguez TR, Rodriguez L, Miranda-Filloy JA, Fernandez-Gutierrez B, et al A1298C polymorphism in the MTHFR gene predisposes to cardiovascular risk in rheumatoid arthritis. Arthritis Res Ther. 2010;12(2): R71 10.1186/ar2989 20423475 [OpenAIRE] [PubMed] [DOI]

7 Hughes LB, Beasley TM, Patel H, Tiwari HK, Morgan SL, Baggott JE, et al Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis. Ann Rheum Dis. 2006;65(9): 1213–1218. 16439441 [OpenAIRE] [PubMed]

8 Brambila-Tapia AJ, Duran-Gonzalez J, Sandoval-Ramirez L, Mena JP, Salazar-Paramo M, Gamez-Nava JI, et al MTHFR C677T, MTHFR A1298C, and OPG A163G polymorphisms in Mexican patients with rheumatoid arthritis and osteoporosis. Dis Markers. 2012;32(2): 109–114. 10.3233/DMA-2011-0868 22377704 [OpenAIRE] [PubMed] [DOI]

9 Lee YH, Song GG. Associations between the C677T and A1298C polymorphisms of MTHFR and the efficacy and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis. Clin Drug Investig. 2010;30(2): 101–108. 10.2165/11531070-000000000-00000 20067328 [OpenAIRE] [PubMed] [DOI]

10 Kobayashi T, Murasawa A, Ito S, Yamamoto K, Komatsu Y, Abe A, et al Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults. J Periodontol. 2009;80(5): 792–799. 10.1902/jop.2009.080573 19405833 [OpenAIRE] [PubMed] [DOI]

11 Menegatti E, Davit A, Francica S, Berardi D, Rossi D, Baldovino S, et al Genetic factors associated with rheumatoid arthritis and systemic vasculitis: evaluation of a panel of polymorphisms. Dis Markers. 2009;27(5): 217–223. 10.3233/DMA-2009-0666 20037209 [OpenAIRE] [PubMed] [DOI]

12 Munoz-Valle JF, Torres-Carrillo NM, Guzman-Guzman IP, Torres-Carrillo N, Ruiz-Quezada SL, Palafox-Sanchez CA, et al The functional class evaluated in rheumatoid arthritis is associated with soluble TGF-beta1 serum levels but not with G915C (Arg25Pro) TGF-beta1 polymorphism. Rheumatol Int. 2012;32(2): 367–372. 10.1007/s00296-010-1624-x 21113716 [OpenAIRE] [PubMed] [DOI]

13 Al-Rayes H, Al-Swailem R, Albelawi M, Arfin M, Al-Asmari A, Tariq M. TNF-alpha and TNF-beta gene polymorphism in Saudi rheumatoid arthritis patients. Clin Med Insights Arthritis Musculoskelet Disord. 2011;4: 55–63. 10.4137/CMAMD.S6941 21792343 [OpenAIRE] [PubMed] [DOI]

14 Steiner G, Tohidast-Akrad M, Witzmann G, Vesely M, Studnicka-Benke A, Gal A, et al Cytokine production by synovial T cells in rheumatoid arthritis. Rheumatology (Oxford). 1999;38(3): 202–213.10325658 [PubMed]

15 Li N, Liu R, Zhai H, Li L, Yin Y, Zhang J, et al Polymorphisms of the LTA gene may contribute to the risk of myocardial infarction: a meta-analysis. PLoS One. 2014;9(3): e92272 10.1371/journal.pone.0092272 24642747 [OpenAIRE] [PubMed] [DOI]

62 references, page 1 of 5
Abstract
Rheumatoid arthritis (RA) is an autoimmune disease which has a significant socio-economic impact. The aim of the current study was to investigate eight candidate RA susceptibility loci to identify the associated variants in Egyptian population. Eight single nucleotide polymorphisms (SNPs) (MTHFR-C677T and A1298C, TGFβ1 T869C, TNFB A252G, and VDR-ApaI, BsmI, FokI, and TaqI) were tested by genotyping patients with RA (n = 105) and unrelated controls (n = 80). Associations were tested using multiplicative, dominant, recessive, and co-dominant models. Also, the linkage disequilibrium (LD) between the VDR SNPs was measured to detect any indirect association. By compa...
Subjects
free text keywords: Medicine, R, Science, Q, Research Article, General Biochemistry, Genetics and Molecular Biology, General Agricultural and Biological Sciences, General Medicine, Methylenetetrahydrofolate reductase, biology.protein, biology, Genetics, TaqI, chemistry.chemical_compound, chemistry, Haplotype, Linkage disequilibrium, Single-nucleotide polymorphism, FokI, business.industry, business, Population, education.field_of_study, education, Allele frequency
Download fromView all 5 versions
PLoS ONE
Article . 2015
PLoS ONE
Article . 2015
Provider: Crossref
PLoS ONE
Article
Provider: UnpayWall
62 references, page 1 of 5

1 Saad MN, Mabrouk MS, Eldeib AM, Shaker OG. Identification of rheumatoid arthritis biomarkers based on single nucleotide polymorphisms and haplotype blocks: a systematic review and meta-analysis. J Adv Res. 2015 10.1016/j.jare.2015.01.008 [OpenAIRE] [DOI]

2 Lewis CM. Genetic association studies: design, analysis and interpretation. Brief Bioinform. 2002;3(2): 146–153. 12139434 [PubMed]

3 Lewis CM, Knight J. Introduction to genetic association studies. Cold Spring Harb Protoc. 2012;2012(3): 297–306. 10.1101/pdb.top068163 22383645 [PubMed] [DOI]

4 The basics of genetic association analysis In: Laird NM, Lange C, editors. The fundamentals of modern statistical genetics: Springer; 2010 pp. 99–108.

5 Rubini M, Padovan M, Baricordi O, Fotinidi M, Govoni M, Trotta F. The c.1298A>C polymorphism in the methylenetetrahydrofolate reductase gene is associated with rheumatoid arthritis susceptibility in Italian patients. Clin Exp Rheumatol. 2008;26(1): 163 18328173 [OpenAIRE] [PubMed]

6 Palomino-Morales R, Gonzalez-Juana tey C, Vazquez-Rodriguez TR, Rodriguez L, Miranda-Filloy JA, Fernandez-Gutierrez B, et al A1298C polymorphism in the MTHFR gene predisposes to cardiovascular risk in rheumatoid arthritis. Arthritis Res Ther. 2010;12(2): R71 10.1186/ar2989 20423475 [OpenAIRE] [PubMed] [DOI]

7 Hughes LB, Beasley TM, Patel H, Tiwari HK, Morgan SL, Baggott JE, et al Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis. Ann Rheum Dis. 2006;65(9): 1213–1218. 16439441 [OpenAIRE] [PubMed]

8 Brambila-Tapia AJ, Duran-Gonzalez J, Sandoval-Ramirez L, Mena JP, Salazar-Paramo M, Gamez-Nava JI, et al MTHFR C677T, MTHFR A1298C, and OPG A163G polymorphisms in Mexican patients with rheumatoid arthritis and osteoporosis. Dis Markers. 2012;32(2): 109–114. 10.3233/DMA-2011-0868 22377704 [OpenAIRE] [PubMed] [DOI]

9 Lee YH, Song GG. Associations between the C677T and A1298C polymorphisms of MTHFR and the efficacy and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis. Clin Drug Investig. 2010;30(2): 101–108. 10.2165/11531070-000000000-00000 20067328 [OpenAIRE] [PubMed] [DOI]

10 Kobayashi T, Murasawa A, Ito S, Yamamoto K, Komatsu Y, Abe A, et al Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults. J Periodontol. 2009;80(5): 792–799. 10.1902/jop.2009.080573 19405833 [OpenAIRE] [PubMed] [DOI]

11 Menegatti E, Davit A, Francica S, Berardi D, Rossi D, Baldovino S, et al Genetic factors associated with rheumatoid arthritis and systemic vasculitis: evaluation of a panel of polymorphisms. Dis Markers. 2009;27(5): 217–223. 10.3233/DMA-2009-0666 20037209 [OpenAIRE] [PubMed] [DOI]

12 Munoz-Valle JF, Torres-Carrillo NM, Guzman-Guzman IP, Torres-Carrillo N, Ruiz-Quezada SL, Palafox-Sanchez CA, et al The functional class evaluated in rheumatoid arthritis is associated with soluble TGF-beta1 serum levels but not with G915C (Arg25Pro) TGF-beta1 polymorphism. Rheumatol Int. 2012;32(2): 367–372. 10.1007/s00296-010-1624-x 21113716 [OpenAIRE] [PubMed] [DOI]

13 Al-Rayes H, Al-Swailem R, Albelawi M, Arfin M, Al-Asmari A, Tariq M. TNF-alpha and TNF-beta gene polymorphism in Saudi rheumatoid arthritis patients. Clin Med Insights Arthritis Musculoskelet Disord. 2011;4: 55–63. 10.4137/CMAMD.S6941 21792343 [OpenAIRE] [PubMed] [DOI]

14 Steiner G, Tohidast-Akrad M, Witzmann G, Vesely M, Studnicka-Benke A, Gal A, et al Cytokine production by synovial T cells in rheumatoid arthritis. Rheumatology (Oxford). 1999;38(3): 202–213.10325658 [PubMed]

15 Li N, Liu R, Zhai H, Li L, Yin Y, Zhang J, et al Polymorphisms of the LTA gene may contribute to the risk of myocardial infarction: a meta-analysis. PLoS One. 2014;9(3): e92272 10.1371/journal.pone.0092272 24642747 [OpenAIRE] [PubMed] [DOI]

62 references, page 1 of 5
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publication . Other literature type . Article . 2015

Genetic Case-Control Study for Eight Polymorphisms Associated with Rheumatoid Arthritis

Saad, Mohamed N.; Mabrouk, Mai S.; Eldeib, Ayman M.; Shaker, Olfat G.;