publication . Article . 2002

Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex

Hideo Nishitani; Eiji Hirose; Yasuhiro Uchimura; Masafumi Nakamura; Makoto Umeda; Kiyomasa Nishii; Nozomu Mori; Takeharu Nishimoto;
  • Published: 25 Jul 2002
  • Publisher: Elsevier BV
Abstract Previously isolated RanBPM, a Ran-binding protein in the microtubule-organizing center, which had been thought to play a role in Ran-stimulated microtubule assembly, turned out to be a truncated protein. To clarify the function of RanBPM, we cloned the full-sized RanBPM cDNA that encodes a 90 kDa protein, compared to the previously isolated cDNA that encoded a 55 kDa protein. The newly cloned 5′ coding region contains a great number of cytidine and guanidine nucleotides, like the CpG island. Thus, full-sized RanBPM cDNA encodes a long stretch of proline and glutamine residues in the N-terminal region. It comprises a protein complex of more than 670 kDa....
free text keywords: Genetics, General Medicine, Microtubule, Nucleotide, chemistry.chemical_classification, chemistry, Centrosome, Cloning, Cytidine, chemistry.chemical_compound, Coding region, Molecular biology, Complementary DNA, Biology, Ran
Related Organizations
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue