publication . Article . Other literature type . 2014

Chitosan/silk fibroin-based, Schwann cell-derived extracellular matrix-modified scaffolds for bridging rat sciatic nerve gaps.

Zhenmeiyu Li; Fei Ding; Chengbin Xue; Yumin Yang; Yun Gu; Jianbin Zhu; Xiaosong Gu;
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  • Published: 01 Feb 2014 Journal: Biomaterials, volume 35, pages 2,253-2,263 (issn: 0142-9612, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Extracellular matrix (ECM) plays a prominent role in establishing and maintaining an ideal microenvironment for tissue regeneration, and ECM scaffolds are used as a feasible alternative to cellular and molecular therapy in the fields of tissue engineering. Because of their advantages over tissue-derived ECM scaffolds, cultured cell-derived ECM scaffolds are beginning to attract attention, but they have been scarcely studied for peripheral nerve repair. Here we aimed to develop a tissue engineered nerve scaffold by reconstituting nerve cell-derived ECM with natural biomaterials. A protocol was adopted to prepare and characterize the cultured Schwann cell (SC)-der...
Subjects
free text keywords: Biophysics, Mechanics of Materials, Bioengineering, Biomaterials, Ceramics and Composites, Tissue engineering, Schwann cell, medicine.anatomical_structure, medicine, Sciatic nerve, Fibroin, Extracellular matrix, Scaffold, Materials science, Biomedical engineering, Decellularization, Regeneration (biology)
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