publication . Article . Other literature type . 2015

Effect of naturally random allocation to lower low-density lipoprotein cholesterol on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both: a 2 × 2 factorial Mendelian randomization study.

Raju Penumetcha; Faisal Majeed; Brian A. Ference; John M. Flack; Robert D. Brook;
Open Access
  • Published: 01 Apr 2015 Journal: Journal of the American College of Cardiology, volume 65, pages 1,552-1,561 (issn: 0735-1097, Copyright policy)
  • Publisher: Elsevier BV
Abstract Background Considerable uncertainty exists as to whether lowering low-density lipoprotein cholesterol (LDL-C) by inhibiting the Niemann-Pick C1-Like 1 (NPC1L1) receptor with ezetimibe, either alone or in combination with a 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) inhibitor (statin), will reduce the risk of coronary heart disease (CHD). Objectives This study evaluated the effect of naturally random allocation to lower LDL-C mediated by polymorphisms in the NPC1L1 gene (target of ezetimibe), the HMGCR gene (target of statins), or both (target of combination therapy) on the risk of CHD. Methods We constructed NPC1L1 and HMGCR genetic LDL-C s...
Medical Subject Headings: lipids (amino acids, peptides, and proteins)
free text keywords: genetic association, statins, Myocardial infarction, medicine.disease, medicine, Odds ratio, Lower risk, Mendelian randomization, Gastroenterology, medicine.medical_specialty, PCSK9, Endocrinology, Internal medicine, Confidence interval, Statin, medicine.drug_class, Ezetimibe, medicine.drug, business.industry, business
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