publication . Article . 2017

Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus

Terkild Brink Buus; Niels Ødum; Carsten Geisler; Jens Peter Holst Lauritsen;
Open Access English
  • Published: 01 Dec 2017 Journal: Nature Communications (issn: 2041-1723, Copyright policy)
  • Publisher: Nature Publishing Group
  • Country: Denmark
Abstract
Mouse γδ T cells have diverse functional subsets, but how these subsets are programmed during their development is still unclear. Here the authors show that three surface markers, CD117, CD200 and CD371, refine the development of γδ T cells in the thymus into three pathways programming distinct γδ T cell subsets.
Subjects
free text keywords: /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428, Journal Article, Science, Q, Article
66 references, page 1 of 5

Bonneville, M, O’Brien, RL, Born, WK. γδ T cell effector functions: a blend of innate programming and acquired plasticity. Nat. Rev. Immunol.. 2010; 10: 467-478 [OpenAIRE] [PubMed] [DOI]

Vantourout, P, Hayday, A. Six-of-the-best: unique contributions of γδ T cells to immunology. Nat. Rev. Immunol.. 2013; 13: 88-100 [OpenAIRE] [PubMed] [DOI]

Chien, YH, Meyer, C, Bonneville, M. γδ T cells: first line of defense and beyond. Annu. Rev. Immunol.. 2014; 32: 121-155 [OpenAIRE] [PubMed] [DOI]

Silva-Santos, B, Serre, K, Norell, H. γδ T cells in cancer. Nat. Rev. Immunol.. 2015; 15: 683-691 [OpenAIRE] [PubMed] [DOI]

Daley, D. γδ T cells support pancreatic oncogenesis by restraining αβ T cell activation. Cell. 2016; 166: 1485-1499.e1415 [OpenAIRE] [PubMed] [DOI]

Turchinovich, G, Hayday, AC. Skint-1 identifies a common molecular mechanism for the development of interferon-γ-secreting versus interleukin-17-secreting γδ T cells. Immunity. 2011; 35: 59-68 [OpenAIRE] [PubMed] [DOI]

Jensen, KD. Thymic selection determines γδ T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon γ. Immunity. 2008; 29: 90-100 [OpenAIRE] [PubMed] [DOI]

Ribot, JC. CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17-producing γδ T cell subsets. Nat. Immunol.. 2009; 10: 427-436 [OpenAIRE] [PubMed] [DOI]

Munoz-Ruiz, M. TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets. Nat. Immunol.. 2016; 17: 721-727 [OpenAIRE] [PubMed] [DOI]

Lombes, A. Adaptive immune-like γ/δ T lymphocytes share many common features with their alpha/beta T cell counterparts. J. Immunol.. 2015; 195: 1449-1458 [OpenAIRE] [PubMed] [DOI]

Ramirez-Valle, F, Gray, EE, Cyster, JG. Inflammation induces dermal Vγ4 + γδT17 memory-like cells that travel to distant skin and accelerate secondary IL-17-driven responses. Proc. Natl Acad. Sci. USA. 2015; 112: 8046-8051 [OpenAIRE] [PubMed] [DOI]

Zeng, X. γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response. Immunity. 2012; 37: 524-534 [OpenAIRE] [PubMed] [DOI]

Hartwig, T, Pantelyushin, S, Croxford, AL, Kulig, P, Becher, B. Dermal IL-17-producing γδ T cells establish long-lived memory in the skin. Eur. J. Immunol.. 2015; 45: 3022-3033 [OpenAIRE] [PubMed] [DOI]

Turchinovich, G, Pennington, DJ. T cell receptor signalling in γδ cell development: strength isn’t everything. Trends Immunol.. 2011; 32: 567-573 [OpenAIRE] [PubMed] [DOI]

Munoz-Ruiz, M, Sumaria, N, Pennington, DJ, Silva-Santos, B. Thymic determinants of γδ T cell differentiation. Trends Immunol.. 2017; 38: 336-344 [OpenAIRE] [PubMed] [DOI]

66 references, page 1 of 5
Abstract
Mouse γδ T cells have diverse functional subsets, but how these subsets are programmed during their development is still unclear. Here the authors show that three surface markers, CD117, CD200 and CD371, refine the development of γδ T cells in the thymus into three pathways programming distinct γδ T cell subsets.
Subjects
free text keywords: /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428, Journal Article, Science, Q, Article
66 references, page 1 of 5

Bonneville, M, O’Brien, RL, Born, WK. γδ T cell effector functions: a blend of innate programming and acquired plasticity. Nat. Rev. Immunol.. 2010; 10: 467-478 [OpenAIRE] [PubMed] [DOI]

Vantourout, P, Hayday, A. Six-of-the-best: unique contributions of γδ T cells to immunology. Nat. Rev. Immunol.. 2013; 13: 88-100 [OpenAIRE] [PubMed] [DOI]

Chien, YH, Meyer, C, Bonneville, M. γδ T cells: first line of defense and beyond. Annu. Rev. Immunol.. 2014; 32: 121-155 [OpenAIRE] [PubMed] [DOI]

Silva-Santos, B, Serre, K, Norell, H. γδ T cells in cancer. Nat. Rev. Immunol.. 2015; 15: 683-691 [OpenAIRE] [PubMed] [DOI]

Daley, D. γδ T cells support pancreatic oncogenesis by restraining αβ T cell activation. Cell. 2016; 166: 1485-1499.e1415 [OpenAIRE] [PubMed] [DOI]

Turchinovich, G, Hayday, AC. Skint-1 identifies a common molecular mechanism for the development of interferon-γ-secreting versus interleukin-17-secreting γδ T cells. Immunity. 2011; 35: 59-68 [OpenAIRE] [PubMed] [DOI]

Jensen, KD. Thymic selection determines γδ T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon γ. Immunity. 2008; 29: 90-100 [OpenAIRE] [PubMed] [DOI]

Ribot, JC. CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17-producing γδ T cell subsets. Nat. Immunol.. 2009; 10: 427-436 [OpenAIRE] [PubMed] [DOI]

Munoz-Ruiz, M. TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets. Nat. Immunol.. 2016; 17: 721-727 [OpenAIRE] [PubMed] [DOI]

Lombes, A. Adaptive immune-like γ/δ T lymphocytes share many common features with their alpha/beta T cell counterparts. J. Immunol.. 2015; 195: 1449-1458 [OpenAIRE] [PubMed] [DOI]

Ramirez-Valle, F, Gray, EE, Cyster, JG. Inflammation induces dermal Vγ4 + γδT17 memory-like cells that travel to distant skin and accelerate secondary IL-17-driven responses. Proc. Natl Acad. Sci. USA. 2015; 112: 8046-8051 [OpenAIRE] [PubMed] [DOI]

Zeng, X. γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response. Immunity. 2012; 37: 524-534 [OpenAIRE] [PubMed] [DOI]

Hartwig, T, Pantelyushin, S, Croxford, AL, Kulig, P, Becher, B. Dermal IL-17-producing γδ T cells establish long-lived memory in the skin. Eur. J. Immunol.. 2015; 45: 3022-3033 [OpenAIRE] [PubMed] [DOI]

Turchinovich, G, Pennington, DJ. T cell receptor signalling in γδ cell development: strength isn’t everything. Trends Immunol.. 2011; 32: 567-573 [OpenAIRE] [PubMed] [DOI]

Munoz-Ruiz, M, Sumaria, N, Pennington, DJ, Silva-Santos, B. Thymic determinants of γδ T cell differentiation. Trends Immunol.. 2017; 38: 336-344 [OpenAIRE] [PubMed] [DOI]

66 references, page 1 of 5
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