publication . Article . 2009

The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis.

A. M. Ashique; Y. Choe; M. Karlen; S. R. May; K. Phamluong; M. J. Solloway; J. Ericson; A. S. Peterson;
  • Published: 03 Nov 2009
Abstract
Regulatory factor X (Rfx) homologs regulate the transcription of genes necessary for ciliogenesis in invertebrates and vertebrates. Primary cilia are necessary for Hedgehog signaling and regulation of the activity of the transcriptional regulators known as Gli proteins, which are targets of Hedgehog signaling. Here, we describe an Rfx4 L298P mouse mutant with distinct dorsoventral patterning defects in the ventral spinal cord and telencephalon due to aberrant Sonic hedgehog (Shh) signaling and Gli3 activity. We find that Ift172 , which encodes an intraflagellar transport protein necessary for ciliogenesis, is a direct transcriptional target of Rfx4, and the decr...
Subjects
Medical Subject Headings: animal structuresembryonic structures
free text keywords: Cell Biology, Biochemistry, Molecular Biology, Biology, Sonic hedgehog, biology.protein, Transcription factor, Hedgehog signaling pathway, Intraflagellar transport, Transcriptional regulation, Cilium, GLI3, Ciliogenesis
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publication . Article . 2009

The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis.

A. M. Ashique; Y. Choe; M. Karlen; S. R. May; K. Phamluong; M. J. Solloway; J. Ericson; A. S. Peterson;