publication . Article . 2015

Targeting inflammation to influence mood following spinal cord injury: a randomized clinical trial

David J. Allison; David S. Ditor;
Open Access English
  • Published: 01 Nov 2015 Journal: Journal of Neuroinflammation, volume 12 (eissn: 1742-2094, Copyright policy)
  • Publisher: BioMed Central
Abstract
The purpose of the present study was to examine the efficacy of targeting inflammation as a means of improving mood following spinal cord injury (SCI) and explore the potential mechanisms of action. The study was a randomized, parallel-group, controlled, clinical trial (NCT02099890) whereby 20 participants with varying levels and severities of SCI were randomized (3:2) to either the treatment group, consisting of a 12-week anti-inflammatory diet, or control group. Outcome measures were assessed at baseline, 1 and 3 months, and consisted of CES-D scores of depression, markers of inflammation as assessed by various pro- and anti-inflammatory cytokines and several ...
Subjects
free text keywords: Research, Depression, Mood, Spinal cord injury, Inflammation, IL-1β, Anti-inflammatory diet, Immunology, Cellular and Molecular Neuroscience, Neurology, General Neuroscience, Subgroup analysis, Mood disorders, medicine.disease, medicine, Kynurenine, chemistry.chemical_compound, chemistry, Gastroenterology, medicine.medical_specialty, Randomized controlled trial, law.invention, law, Physical therapy, Kynurenine pathway, Center for Epidemiologic Studies Depression Scale, Internal medicine, business.industry, business
Related Organizations
41 references, page 1 of 3

Maes, M. Major depression and activation of the inflammatory response system. Adv Exp Med Biol. 1999; 461: 25-46 [OpenAIRE] [PubMed] [DOI]

Sluzewska, A. Indicators of immune activation in depressed patients. Adv Exp Med Biol. 1999; 461: 59-73 [OpenAIRE] [PubMed] [DOI]

Maes, M, Lambrechts, J, Bosmans, E, Jacobs, J, Suy, E, Vandervorst, C. Evidence for a systemic immune activation during depression: results of leukocyte enumeration by flow cytometry in conjunction with monoclonal antibody staining. Psychol Med. 1992; 22: 45-53 [OpenAIRE] [PubMed] [DOI]

Allison, DJ, Ditor, DS. The common inflammatory etiology of depression and cognitive impairment: a therapeutic target. J Neuroinflammation. 2014; 11: 151 [OpenAIRE] [PubMed] [DOI]

Watkins, LR, Maier, SF, Goehler, LE. Cytokine-to-brain communication: a review & analysis of alternative mechanisms. Life Sci. 1995; 57: 1011-1026 [PubMed] [DOI]

Banks, WA, Ortiz, L, Plotkin, SR, Kastin, AJ. Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism. J Pharmacol Exp Ther. 1991; 259: 988-996 [OpenAIRE] [PubMed]

Zhu, C-B, Blakely, RD, Hewlett, WA. The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters. Neuropsychopharmacology. 2006; 31: 2121-2131 [PubMed]

Hirschfeld, RMA. History and evolution of the monoamine hypothesis of depression. J Clin Psychiatry. 2000; 61 (Suppl 6): 4-6 [PubMed]

Ramamoorthy, S, Ramamoorthy, JD, Prasad, PD, Bhat, GK, Mahesh, VB, Leibach, FH, Ganapathy, V. Regulation of the human serotonin transporter by interleukin-1B. Biochem Biophys Res Commun. 1995; 216: 560-567 [OpenAIRE] [PubMed] [DOI]

Oxenkrug, GF. Genetic and hormonal regulation of tryptophan kynurenine metabolism: implications for vascular cognitive impairment, major depressive disorder, and aging. Ann N Y Acad Sci. 2007; 1122: 35-49 [OpenAIRE] [PubMed] [DOI]

Gál, EM, Sherman, AD. L-kynurenine: its synthesis and possible regulatory function in brain. Neurochem Res. 1980; 5: 223-239 [PubMed] [DOI]

Davies, AL, Hayes, KC, Dekaban, GA. Clinical correlates of elevated serum concentrations of cytokines and autoantibodies in patients with spinal cord injury. Arch Phys Med Rehabil. 2007; 88: 1384-1393 [OpenAIRE] [PubMed] [DOI]

Hayes, KC, Hull, TCL, Delaney, GA, Potter, PJ, Sequeira, KAJ, Campbell, K. Elevated serum titers of proinflammatory cytokines and CNS autoantibodies in patients with chronic spinal cord injury. J Neurotrauma. 2002; 19: 753-761 [OpenAIRE] [PubMed] [DOI]

Gibson, AE, Buchholz, AC, Martin Ginis, KA. C-Reactive protein in adults with chronic spinal cord injury: increased chronic inflammation in tetraplegia vs paraplegia. Spinal Cord. 2008; 46: 616-621 [OpenAIRE] [PubMed] [DOI]

Liang, H, Mojtahedi, MC, Chen, D, Braunschweig, CL. Elevated C-reactive protein associated with decreased high-density lipoprotein cholesterol in men with spinal cord injury. Arch Phys Med Rehabil. 2008; 89: 36-41 [OpenAIRE] [PubMed] [DOI]

41 references, page 1 of 3
Abstract
The purpose of the present study was to examine the efficacy of targeting inflammation as a means of improving mood following spinal cord injury (SCI) and explore the potential mechanisms of action. The study was a randomized, parallel-group, controlled, clinical trial (NCT02099890) whereby 20 participants with varying levels and severities of SCI were randomized (3:2) to either the treatment group, consisting of a 12-week anti-inflammatory diet, or control group. Outcome measures were assessed at baseline, 1 and 3 months, and consisted of CES-D scores of depression, markers of inflammation as assessed by various pro- and anti-inflammatory cytokines and several ...
Subjects
free text keywords: Research, Depression, Mood, Spinal cord injury, Inflammation, IL-1β, Anti-inflammatory diet, Immunology, Cellular and Molecular Neuroscience, Neurology, General Neuroscience, Subgroup analysis, Mood disorders, medicine.disease, medicine, Kynurenine, chemistry.chemical_compound, chemistry, Gastroenterology, medicine.medical_specialty, Randomized controlled trial, law.invention, law, Physical therapy, Kynurenine pathway, Center for Epidemiologic Studies Depression Scale, Internal medicine, business.industry, business
Related Organizations
41 references, page 1 of 3

Maes, M. Major depression and activation of the inflammatory response system. Adv Exp Med Biol. 1999; 461: 25-46 [OpenAIRE] [PubMed] [DOI]

Sluzewska, A. Indicators of immune activation in depressed patients. Adv Exp Med Biol. 1999; 461: 59-73 [OpenAIRE] [PubMed] [DOI]

Maes, M, Lambrechts, J, Bosmans, E, Jacobs, J, Suy, E, Vandervorst, C. Evidence for a systemic immune activation during depression: results of leukocyte enumeration by flow cytometry in conjunction with monoclonal antibody staining. Psychol Med. 1992; 22: 45-53 [OpenAIRE] [PubMed] [DOI]

Allison, DJ, Ditor, DS. The common inflammatory etiology of depression and cognitive impairment: a therapeutic target. J Neuroinflammation. 2014; 11: 151 [OpenAIRE] [PubMed] [DOI]

Watkins, LR, Maier, SF, Goehler, LE. Cytokine-to-brain communication: a review & analysis of alternative mechanisms. Life Sci. 1995; 57: 1011-1026 [PubMed] [DOI]

Banks, WA, Ortiz, L, Plotkin, SR, Kastin, AJ. Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism. J Pharmacol Exp Ther. 1991; 259: 988-996 [OpenAIRE] [PubMed]

Zhu, C-B, Blakely, RD, Hewlett, WA. The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters. Neuropsychopharmacology. 2006; 31: 2121-2131 [PubMed]

Hirschfeld, RMA. History and evolution of the monoamine hypothesis of depression. J Clin Psychiatry. 2000; 61 (Suppl 6): 4-6 [PubMed]

Ramamoorthy, S, Ramamoorthy, JD, Prasad, PD, Bhat, GK, Mahesh, VB, Leibach, FH, Ganapathy, V. Regulation of the human serotonin transporter by interleukin-1B. Biochem Biophys Res Commun. 1995; 216: 560-567 [OpenAIRE] [PubMed] [DOI]

Oxenkrug, GF. Genetic and hormonal regulation of tryptophan kynurenine metabolism: implications for vascular cognitive impairment, major depressive disorder, and aging. Ann N Y Acad Sci. 2007; 1122: 35-49 [OpenAIRE] [PubMed] [DOI]

Gál, EM, Sherman, AD. L-kynurenine: its synthesis and possible regulatory function in brain. Neurochem Res. 1980; 5: 223-239 [PubMed] [DOI]

Davies, AL, Hayes, KC, Dekaban, GA. Clinical correlates of elevated serum concentrations of cytokines and autoantibodies in patients with spinal cord injury. Arch Phys Med Rehabil. 2007; 88: 1384-1393 [OpenAIRE] [PubMed] [DOI]

Hayes, KC, Hull, TCL, Delaney, GA, Potter, PJ, Sequeira, KAJ, Campbell, K. Elevated serum titers of proinflammatory cytokines and CNS autoantibodies in patients with chronic spinal cord injury. J Neurotrauma. 2002; 19: 753-761 [OpenAIRE] [PubMed] [DOI]

Gibson, AE, Buchholz, AC, Martin Ginis, KA. C-Reactive protein in adults with chronic spinal cord injury: increased chronic inflammation in tetraplegia vs paraplegia. Spinal Cord. 2008; 46: 616-621 [OpenAIRE] [PubMed] [DOI]

Liang, H, Mojtahedi, MC, Chen, D, Braunschweig, CL. Elevated C-reactive protein associated with decreased high-density lipoprotein cholesterol in men with spinal cord injury. Arch Phys Med Rehabil. 2008; 89: 36-41 [OpenAIRE] [PubMed] [DOI]

41 references, page 1 of 3
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publication . Article . 2015

Targeting inflammation to influence mood following spinal cord injury: a randomized clinical trial

David J. Allison; David S. Ditor;