publication . Article . Other literature type . 2007

PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses

Shaun Purcell; Benjamin Neale; Kathe Todd-Brown; Lori Thomas; Manuel A R Ferreira; David Bender; Julian Maller; Pamela Sklar; Paul I W de Bakker; Mark J Daly; ...
Open Access
  • Published: 01 Sep 2007 Journal: The American Journal of Human Genetics, volume 81, issue 3, pages 559-575 (issn: 0002-9297, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Whole-genome association studies (WGAS) bring new computational, as well as analytic, challenges to researchers. Many existing genetic-analysis tools are not designed to handle such large data sets in a convenient manner and do not necessarily exploit the new opportunities that whole-genome data bring. To address these issues, we developed PLINK, an open-source C/C++ WGAS tool set. With PLINK, large data sets comprising hundreds of thousands of markers genotyped for thousands of individuals can be rapidly manipulated and analyzed in their entirety. As well as providing tools to make the basic analytic steps computationally efficient, PLINK also supports some nov...
Subjects
free text keywords: Genetics(clinical), Genetics, Report, 1000 Genomes Project, Population, education.field_of_study, education, Imputation (genetics), Data management, business.industry, business, International HapMap Project, Genetic association, Population stratification, Biology, Identity by descent
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