publication . Other literature type . 2013

Cognitive reserve associated with FDG-PET in preclinical Alzheimer disease

Ewers, Michael; Insel, Philip S.; Stern, Yaakov; Weiner, Michael W.;
Open Access English
  • Published: 26 Mar 2013
  • Publisher: Lippincott Williams & Wilkins
Abstract
OBJECTIVE: To examine the effect of education (a surrogate measure of cognitive reserve) on FDG-PET brain metabolism in elderly cognitively healthy (HC) subjects with preclinical Alzheimer disease (AD). METHODS: Fifty-two HC subjects (mean age 75 years) with FDG-PET and CSF measurement of Abeta1-42 were included from the prospective Alzheimer's Disease Neuroimaging Initiative biomarker study. HC subjects received a research classification of preclinical AD if CSF Abeta1-42 was <192 pg/mL (Abeta1-42 [+]) vs HC with normal Abeta (Abeta1-42 [-]). In regression analyses, we tested the interaction effect between education and CSF Abeta1-42 status (Abeta1-42 [+] vs...
Subjects
Medical Subject Headings: nervous systemmental disorders
free text keywords: Article, Neurology, Alzheimer's disease, Cognition, Education, Brain--Metabolism
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publication . Other literature type . 2013

Cognitive reserve associated with FDG-PET in preclinical Alzheimer disease

Ewers, Michael; Insel, Philip S.; Stern, Yaakov; Weiner, Michael W.;