publication . Article . 2013

The emerging role of dietary fructose in obesity and cognitive decline.

Lakhan, Shaheen E; Kirchgessner, Annette;
Open Access English
  • Published: 01 Aug 2013 Journal: Nutrition Journal, volume 12, issue 1 (issn: 1475-2891, Copyright policy)
  • Publisher: Springer Nature
Abstract
The incidence of obesity has increased dramatically over the past several years, and in parallel, so has the prevalence of type 2 diabetes (T2D). Numerous studies have demonstrated that both obesity and T2D are associated with lower cognitive performance, cognitive decline, and dementia. Intake of dietary fructose has also increased. In fact, high-fructose corn syrup (HFCS) accounts for as much as 40% of caloric sweeteners used in the United States. Given the increase in the incidence of Alzheimer’s disease (AD), characterized by an age-related decline in memory and cognitive functioning, in this report we review the effects of obesity on cognitive performance a...
Subjects
free text keywords: Nutrition and Dietetics, Medicine (miscellaneous), Review, Nutrition, Fructose, Diabetes, Omega-3 fatty acids, Obesity, medicine.disease, medicine, Endocrinology, medicine.medical_specialty, Effects of sleep deprivation on cognitive performance, Type 2 diabetes, Cognition, business.industry, business, Internal medicine, Corn syrup, food.ingredient, food, Diabetes mellitus, Dementia, Cognitive decline
Related Organizations
164 references, page 1 of 11

Obesity: preventing and managing the global epidemic: report of a WHO consultation. World Health Organ Tech Rep Ser. 2000; 894: 1-253

WHO technical report. Obesity-preventing and managing the global epidemic. 2000

Hedley, AA, Ogden, CL, Johnson, CL. Prevalence of overweight and obesity among US children, adolescents, and adults, 1999–2002. JAMA. 2004; 291: 2847-2850 [OpenAIRE] [PubMed] [DOI]

Visscher, TL, Seidell, JC, Menotti, A. Underweight and overweight in relation to mortality among men aged 40–59 and 50–69 years: the Seven Countries Study. Am J Epidemiol. 2000; 15: 660-666 [OpenAIRE] [PubMed]

Controlling the global obesity epidemic. 2011

Flynn, MA, McNell, DA, Maloff, B, Mutasingwa, D, Wu, M, Ford, C, Tough, SC. Reducing obesity and related chronic disease risk in children and youth: a synthesis of evidence with “best practice” recommendations. Obes Rev. 2006; Suppl 1: 7-66 [OpenAIRE] [PubMed]

Halbach, SM, Flynn, J. Treatment of obesity-related hypertension in children and adolescents. Curr Hypertens Rep. 2013; 15 (3): 224-231 [OpenAIRE] [PubMed] [DOI]

Moreno, G, Johnson-Shelton, D, Boles, S. Prevalence and prediction of overweight and obesity among elementary school students. J Sch Health. 2013; 83: 157-163 [OpenAIRE] [PubMed] [DOI]

Danaei, G, Finucane, MM, Lu, Y, Singh, GM, Cowan, MJ. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet. 2011; 378: 31-40 [OpenAIRE] [PubMed] [DOI]

Steinman, M, Lee, S, John Boscardin, W, Miao, Y, Fung, K, Moore, K. Patterns of multimorbidity in elderly veterans. J Am Geriatr Soc. 2012; 60: 1872-1880 [OpenAIRE] [PubMed] [DOI]

Wild, S, Roglic, G, Green, A, Sicree, R, King, H. Global prevalence of diabetes. Diabetes Care. 2004; 27: 1047-1053 [OpenAIRE] [PubMed] [DOI]

Katsumata, Y, Todoriki, H, Higashiuesato, Y, Yasura, S, Willcox, DC. Metabolic syndrome and cognitive decline among the oldest old in Okinawa: in search of a mechanism: the KOCOA project. J Gerontol A Biol Sci Med Sci. 2012; 67A: 126-134 [OpenAIRE] [PubMed] [DOI]

Ervin, RB. Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States. Nat Statistics Rep. 2009; 13: 1-8

De Rerranti, SD, Gauvreau, K, Ludwig, DS, Neufeld, EJ, Newburger, JW, Rifal, N. Prevalence of the metabolic syndrome in American adolescents: findings from the third national health and nutrition examination survey. Circulation. 2004; 110: 2494-2499 [OpenAIRE] [PubMed] [DOI]

Xu, WL, Atti, AR, Gatz, M, Pedersen, NL, Johansson, B, Fratiglioni, L. Midlife overweight and obesity increase late-life dementia risk. Neurology. 2011; 76: 1568-1574 [OpenAIRE] [PubMed] [DOI]

164 references, page 1 of 11
Abstract
The incidence of obesity has increased dramatically over the past several years, and in parallel, so has the prevalence of type 2 diabetes (T2D). Numerous studies have demonstrated that both obesity and T2D are associated with lower cognitive performance, cognitive decline, and dementia. Intake of dietary fructose has also increased. In fact, high-fructose corn syrup (HFCS) accounts for as much as 40% of caloric sweeteners used in the United States. Given the increase in the incidence of Alzheimer’s disease (AD), characterized by an age-related decline in memory and cognitive functioning, in this report we review the effects of obesity on cognitive performance a...
Subjects
free text keywords: Nutrition and Dietetics, Medicine (miscellaneous), Review, Nutrition, Fructose, Diabetes, Omega-3 fatty acids, Obesity, medicine.disease, medicine, Endocrinology, medicine.medical_specialty, Effects of sleep deprivation on cognitive performance, Type 2 diabetes, Cognition, business.industry, business, Internal medicine, Corn syrup, food.ingredient, food, Diabetes mellitus, Dementia, Cognitive decline
Related Organizations
164 references, page 1 of 11

Obesity: preventing and managing the global epidemic: report of a WHO consultation. World Health Organ Tech Rep Ser. 2000; 894: 1-253

WHO technical report. Obesity-preventing and managing the global epidemic. 2000

Hedley, AA, Ogden, CL, Johnson, CL. Prevalence of overweight and obesity among US children, adolescents, and adults, 1999–2002. JAMA. 2004; 291: 2847-2850 [OpenAIRE] [PubMed] [DOI]

Visscher, TL, Seidell, JC, Menotti, A. Underweight and overweight in relation to mortality among men aged 40–59 and 50–69 years: the Seven Countries Study. Am J Epidemiol. 2000; 15: 660-666 [OpenAIRE] [PubMed]

Controlling the global obesity epidemic. 2011

Flynn, MA, McNell, DA, Maloff, B, Mutasingwa, D, Wu, M, Ford, C, Tough, SC. Reducing obesity and related chronic disease risk in children and youth: a synthesis of evidence with “best practice” recommendations. Obes Rev. 2006; Suppl 1: 7-66 [OpenAIRE] [PubMed]

Halbach, SM, Flynn, J. Treatment of obesity-related hypertension in children and adolescents. Curr Hypertens Rep. 2013; 15 (3): 224-231 [OpenAIRE] [PubMed] [DOI]

Moreno, G, Johnson-Shelton, D, Boles, S. Prevalence and prediction of overweight and obesity among elementary school students. J Sch Health. 2013; 83: 157-163 [OpenAIRE] [PubMed] [DOI]

Danaei, G, Finucane, MM, Lu, Y, Singh, GM, Cowan, MJ. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet. 2011; 378: 31-40 [OpenAIRE] [PubMed] [DOI]

Steinman, M, Lee, S, John Boscardin, W, Miao, Y, Fung, K, Moore, K. Patterns of multimorbidity in elderly veterans. J Am Geriatr Soc. 2012; 60: 1872-1880 [OpenAIRE] [PubMed] [DOI]

Wild, S, Roglic, G, Green, A, Sicree, R, King, H. Global prevalence of diabetes. Diabetes Care. 2004; 27: 1047-1053 [OpenAIRE] [PubMed] [DOI]

Katsumata, Y, Todoriki, H, Higashiuesato, Y, Yasura, S, Willcox, DC. Metabolic syndrome and cognitive decline among the oldest old in Okinawa: in search of a mechanism: the KOCOA project. J Gerontol A Biol Sci Med Sci. 2012; 67A: 126-134 [OpenAIRE] [PubMed] [DOI]

Ervin, RB. Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States. Nat Statistics Rep. 2009; 13: 1-8

De Rerranti, SD, Gauvreau, K, Ludwig, DS, Neufeld, EJ, Newburger, JW, Rifal, N. Prevalence of the metabolic syndrome in American adolescents: findings from the third national health and nutrition examination survey. Circulation. 2004; 110: 2494-2499 [OpenAIRE] [PubMed] [DOI]

Xu, WL, Atti, AR, Gatz, M, Pedersen, NL, Johansson, B, Fratiglioni, L. Midlife overweight and obesity increase late-life dementia risk. Neurology. 2011; 76: 1568-1574 [OpenAIRE] [PubMed] [DOI]

164 references, page 1 of 11
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publication . Article . 2013

The emerging role of dietary fructose in obesity and cognitive decline.

Lakhan, Shaheen E; Kirchgessner, Annette;