publication . Article . Other literature type . 2007

Nanotoxicity of iron oxide nanoparticle internalization in growing neurons.

Sungho Jin; Thomas R. Pisanic; Jennifer D. Blackwell; Veronica I. Shubayev; Rita R. Fiñones;
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  • Published: 01 Jun 2007 Journal: Biomaterials, volume 28, pages 2,572-2,581 (issn: 0142-9612, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Magnetic nanoparticles (MNPs) have shown great promise for use as tools in a wide variety of biomedical applications, some of which require the delivery of large numbers of MNPs onto or into the cells of interest. Here we develop a quantifiable model cell system and show that intracellular delivery of even moderate levels of iron oxide (Fe(2)O(3)) nanoparticles may adversely affect cell function. More specifically, we show that exposure to increasing concentrations of anionic MNPs, from 0.15 to 15 mm of iron, results in a dose-dependent diminishing viability and capacity of PC12 cells to extend neurites in response to their putative biological cue, i.e. nerve gr...
Subjects
free text keywords: Magnetic nanoparticles, Cytotoxicity, Intracellular, Nanoparticle, Materials science, Biophysics, Nanotoxicology, Nanotechnology, Iron oxide, chemistry.chemical_compound, chemistry, Internalization, media_common.quotation_subject, media_common, Biocompatibility
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