publication . Other literature type . Article . 2010

Metastatic Growth from Dormant Cells Induced by a Col-I Enriched Fibrotic Environment

D. Barkan; L. H. El Touny; A. M. Michalowski; J. A. Smith; I. Chu; A. S. Davis; J. D. Webster; S. Hoover; R. M. Simpson; J. Gauldie; ...
Open Access English
  • Published: 22 Jun 2010
Abstract
Breast cancer that recurs as metastatic disease many years after primary tumor resection and adjuvant therapy seems to arise from tumor cells that disseminated early in the course of disease but did not develop into clinically apparent lesions. These long-term surviving, disseminated tumor cells maintain a state of dormancy, but may be triggered to proliferate through largely unknown factors. We now show that the induction of fibrosis, associated with deposition of type I collagen (Col-I) in the in vivo metastatic microenvironment, induces dormant D2.0R cells to form proliferative metastatic lesions through β1-integrin signaling. In vitro studies using a three-d...
Subjects
free text keywords: Article, Transforming growth factor beta, biology.protein, biology, Signal transduction, Cancer research, Myosin light-chain kinase, Metastasis, medicine.disease, medicine, Extracellular matrix, Focal adhesion, Immunology, Stress fiber, Proto-oncogene tyrosine-protein kinase Src
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