publication . Article . 2016

Precise image-guided irradiation of small animals: a flexible non-profit platform.

Mechthild Krause; Steffen Löck; Robert Haase; Michael Baumann;
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  • Published: 23 Mar 2016 Journal: Physics in Medicine and Biology, volume 61, pages 3,084-3,108 (issn: 0031-9155, eissn: 1361-6560, Copyright policy)
  • Publisher: IOP Publishing
  • Country: Germany
Abstract
: Preclinical in vivo studies using small animals are essential to develop new therapeutic options in radiation oncology. Of particular interest are orthotopic tumour models, which better reflect the clinical situation in terms of growth patterns and microenvironmental parameters of the tumour as well as the interplay of tumours with the surrounding normal tissues. Such orthotopic models increase the technical demands and the complexity of preclinical studies as local irradiation with therapeutically relevant doses requires image-guided target localisation and accurate beam application. Moreover, advanced imaging techniques are needed for monitoring treatment ou...
Subjects
free text keywords: translational cancer research, small animal research platform, image-guided radiotherapy (IGRT), cone beam computed tomography (CBCT), orthotopic tumour models, precision irradiation, X-ray dosimetry, Radiological and Ultrasound Technology, Radiology Nuclear Medicine and imaging
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