publication . Other literature type . Article . 2013

TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons

RT Smolenski;
Open Access
  • Published: 11 Mar 2013
  • Publisher: Proceedings of the National Academy of Sciences
Abstract
Toll-like receptors (TLRs) are the central players in innate immunity. In particular, TLR9 initiates inflammatory response by recognizing DNA, imported by infection or released from tissue damage. Inflammation is, however, harmful to terminally differentiated organs, such as the heart and brain, with poor regenerative capacity, yet the role of TLR9 in such nonimmune cells, including cardiomyocytes and neurons, is undefined. Here we uncover an unexpected role of TLR9 in energy metabolism and cellular protection in cardiomyocytes and neurons. TLR9 stimulation reduced energy substrates and increased the AMP/ATP ratio, subsequently activating AMP-activated kinase (A...
Subjects
Medical Subject Headings: chemical and pharmacologic phenomena
free text keywords: Multidisciplinary, Biological Sciences
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