publication . Article . Other literature type . 2006

Study of the interaction of an anticancer drug with human and bovine serum albumin: spectroscopic approach.

Omkar Ijare;
Restricted
  • Published: 01 May 2006 Journal: Journal of Pharmaceutical and Biomedical Analysis, volume 41, pages 393-399 (issn: 0731-7085, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Abstract The interactions between gemcitabine hydrochloride (GEM) and bovine serum albumin (BSA) or human serum albumin (HSA) have been studied by spectroscopic techniques. By the analysis of fluorescence spectrum and fluorescence intensity, it was observed that the GEM has a strong ability to quench the intrinsic fluorescence of both BSA and HSA through a static quenching procedure. The association constants of GEM with BSA and HSA were determined at different temperatures based on fluorescence quenching results. The negative ΔH° and positive ΔS° values in case of GEM–BSA and GEM–HSA complexes showed that both hydrogen bonds and hydrophobic interactions play a ...
Subjects
arXiv: Physics::Biological PhysicsPhysics::Medical PhysicsPhysics::Instrumentation and DetectorsQuantitative Biology::Biomolecules
Medical Subject Headings: endocrine system diseasesbody regionsembryonic structures
free text keywords: Analytical Chemistry, Spectroscopy, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science
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