research data . Dataset . 2017

How driving endonuclease genes can be used to combat pests and disease vectors

H. Godfray; Ace North; Burt, Austin;
  • Published: 12 Sep 2017
  • Publisher: Figshare
Abstract
Abstract Driving endonuclease genes (DEGs) spread through a population by a non-Mendelian mechanism. In a heterozygote, the protein encoded by a DEG causes a double-strand break in the homologous chromosome opposite to where its gene is inserted and when the break is repaired using the homologue as a template the DEG heterozygote is converted to a homozygote. Some DEGs occur naturally while several classes of endonucleases can be engineered to spread in this way, with CRISPR-Cas9 based systems being particu
Subjects
Medical Subject Headings: genetic structuressense organspsychological phenomena and processesbehavioral disciplines and activities
free text keywords: Genetics, Neuroscience, Biotechnology, Ecology, 19999 Mathematical Sciences not elsewhere classified
Download fromView all 2 versions
figshare
Dataset . 2017
Provider: Datacite
figshare
Dataset . 2017
Provider: Datacite
Abstract
Abstract Driving endonuclease genes (DEGs) spread through a population by a non-Mendelian mechanism. In a heterozygote, the protein encoded by a DEG causes a double-strand break in the homologous chromosome opposite to where its gene is inserted and when the break is repaired using the homologue as a template the DEG heterozygote is converted to a homozygote. Some DEGs occur naturally while several classes of endonucleases can be engineered to spread in this way, with CRISPR-Cas9 based systems being particu
Subjects
Medical Subject Headings: genetic structuressense organspsychological phenomena and processesbehavioral disciplines and activities
free text keywords: Genetics, Neuroscience, Biotechnology, Ecology, 19999 Mathematical Sciences not elsewhere classified
Download fromView all 2 versions
figshare
Dataset . 2017
Provider: Datacite
figshare
Dataset . 2017
Provider: Datacite
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