publication . Article . Other literature type . 2019

Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data

Shungin, Dmitry; Haworth, Simon; Divaris, Kimon; Agler, Cary S.; Kamatani, Yoichiro; Keun Lee, Myoung; Grinde, Kelsey; Hindy, George; Alaraudanjoki, Viivi; Pesonen, Paula; ...
Open Access English
  • Published: 24 Jun 2019
Abstract
Dental caries and periodontitis are among the most common medical conditions. Here, the authors report a GWAS for measures of oral health that reveals 47 risk loci for caries, find genetic correlation with 31 other complex traits and use Mendelian randomization analyses to explore potential causal relationships.
Subjects
Medical Subject Headings: stomatognathic diseases
free text keywords: Dental Caries/epidemiology, Genetic Predisposition to Disease, Genome-Wide Association Study, Genomics, Heredity, Humans, Mendelian Randomization Analysis, Periodontitis/epidemiology, Polymorphism, Single Nucleotide, Quantitative Trait Loci/genetics, Self Report/statistics & numerical data, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428, Journal Article, /dk/atira/pure/researchoutput/pubmedpublicationtype/D017418, Meta-Analysis, /dk/atira/pure/researchoutput/pubmedpublicationtype/D013485, Research Support, Non-U.S. Gov't, Dentistry, Odontologi, General Biochemistry, Genetics and Molecular Biology, General Physics and Astronomy, General Chemistry, Environmental health, Periodontitis, medicine.disease, medicine, Genetic correlation, Genetics, Mendelian randomization, medicine.disease_cause, Medical genetics, medicine.medical_specialty, Biology, Science, Q, Article, Genome-wide association studies, Oral diseases, Epidemiology
Funded by
WT
Project
  • Funder: Wellcome Trust (WT)
,
NIH| Human genomics analysis interface for FaceBase 2
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01DE024425-01
  • Funding stream: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
72 references, page 1 of 5

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017; 390: 1211-1259 [OpenAIRE] [PubMed] [DOI]

Vos, T. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012; 380: 2163-2196 [OpenAIRE] [PubMed] [DOI]

Righolt, AJ, Jevdjevic, M, Marcenes, W, Listl, S. Global-, regional-, and country-level economic impacts of dental diseases in 2015. J. Dent. Res.. 2018; 97: 501-507 [OpenAIRE] [PubMed] [DOI]

Bretz, WA. Longitudinal analysis of heritability for dental caries traits. J. Dent. Res.. 2005; 84: 1047-1051 [OpenAIRE] [PubMed] [DOI]

Michalowicz, BS. Evidence of a substantial genetic basis for risk of adult periodontitis. J. Periodontol.. 2000; 71: 1699-1707 [OpenAIRE] [PubMed] [DOI]

Wang, XJ. Genome-wide association Scan of dental caries in the permanent dentition. Bmc Oral. Health. 2012; 12: 10 [OpenAIRE] [PubMed] [DOI]

Morrison, J. Genome-wide association study of dental caries in the Hispanic Communities Health Study/Study of Latinos (HCHS/SOL). Hum. Molec. Genet. 2016; 25: 807-816 [OpenAIRE] [PubMed] [DOI]

Haworth, S. Consortium-based genome-wide meta-analysis for childhood dental caries traits. Hum. Molec. Genet. 2018; 27: 3113-3127 [OpenAIRE] [PubMed] [DOI]

Nibali, L, Iorio, AD, Tu, YK, Vieira, AR. Host genetics role in the pathogenesis of periodontal disease and caries. J. Clin. Periodontol.. 2017; 44: S52-S78 [OpenAIRE] [PubMed] [DOI]

Timpson, NJ, Greenwood, CMT, Soranzo, N, Lawson, DJ, Richards, JB. Genetic architecture: the shape of the genetic contribution to human traits and disease. Nat. Rev. Genet.. 2017; 19: 110 [OpenAIRE] [PubMed] [DOI]

Teumer, A. Genome-wide association study of chronic periodontitis in a general German population. J. Clin. Periodontol.. 2013; 40: 977-985 [OpenAIRE] [PubMed] [DOI]

Shaffer, JR. Genome-wide association study of periodontal health measured by probing depth in adults ages 18–49 years. G3 (Bethesda). 2014; 4: 307-314 [OpenAIRE] [PubMed] [DOI]

Munz, M. A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis. Hum. Molec. Genet. 2018; 26: 2577-2588 [OpenAIRE] [DOI]

Divaris, K. Genome-wide association study of periodontal pathogen colonization. J. Den. Res. 2012; 91: S21-S28 [OpenAIRE] [DOI]

Offenbacher, S. Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease. Hum. Molec. Genet. 2016; 25: 2113-2129 [OpenAIRE] [PubMed] [DOI]

72 references, page 1 of 5
Abstract
Dental caries and periodontitis are among the most common medical conditions. Here, the authors report a GWAS for measures of oral health that reveals 47 risk loci for caries, find genetic correlation with 31 other complex traits and use Mendelian randomization analyses to explore potential causal relationships.
Subjects
Medical Subject Headings: stomatognathic diseases
free text keywords: Dental Caries/epidemiology, Genetic Predisposition to Disease, Genome-Wide Association Study, Genomics, Heredity, Humans, Mendelian Randomization Analysis, Periodontitis/epidemiology, Polymorphism, Single Nucleotide, Quantitative Trait Loci/genetics, Self Report/statistics & numerical data, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428, Journal Article, /dk/atira/pure/researchoutput/pubmedpublicationtype/D017418, Meta-Analysis, /dk/atira/pure/researchoutput/pubmedpublicationtype/D013485, Research Support, Non-U.S. Gov't, Dentistry, Odontologi, General Biochemistry, Genetics and Molecular Biology, General Physics and Astronomy, General Chemistry, Environmental health, Periodontitis, medicine.disease, medicine, Genetic correlation, Genetics, Mendelian randomization, medicine.disease_cause, Medical genetics, medicine.medical_specialty, Biology, Science, Q, Article, Genome-wide association studies, Oral diseases, Epidemiology
Funded by
WT
Project
  • Funder: Wellcome Trust (WT)
,
NIH| Human genomics analysis interface for FaceBase 2
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01DE024425-01
  • Funding stream: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
72 references, page 1 of 5

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017; 390: 1211-1259 [OpenAIRE] [PubMed] [DOI]

Vos, T. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012; 380: 2163-2196 [OpenAIRE] [PubMed] [DOI]

Righolt, AJ, Jevdjevic, M, Marcenes, W, Listl, S. Global-, regional-, and country-level economic impacts of dental diseases in 2015. J. Dent. Res.. 2018; 97: 501-507 [OpenAIRE] [PubMed] [DOI]

Bretz, WA. Longitudinal analysis of heritability for dental caries traits. J. Dent. Res.. 2005; 84: 1047-1051 [OpenAIRE] [PubMed] [DOI]

Michalowicz, BS. Evidence of a substantial genetic basis for risk of adult periodontitis. J. Periodontol.. 2000; 71: 1699-1707 [OpenAIRE] [PubMed] [DOI]

Wang, XJ. Genome-wide association Scan of dental caries in the permanent dentition. Bmc Oral. Health. 2012; 12: 10 [OpenAIRE] [PubMed] [DOI]

Morrison, J. Genome-wide association study of dental caries in the Hispanic Communities Health Study/Study of Latinos (HCHS/SOL). Hum. Molec. Genet. 2016; 25: 807-816 [OpenAIRE] [PubMed] [DOI]

Haworth, S. Consortium-based genome-wide meta-analysis for childhood dental caries traits. Hum. Molec. Genet. 2018; 27: 3113-3127 [OpenAIRE] [PubMed] [DOI]

Nibali, L, Iorio, AD, Tu, YK, Vieira, AR. Host genetics role in the pathogenesis of periodontal disease and caries. J. Clin. Periodontol.. 2017; 44: S52-S78 [OpenAIRE] [PubMed] [DOI]

Timpson, NJ, Greenwood, CMT, Soranzo, N, Lawson, DJ, Richards, JB. Genetic architecture: the shape of the genetic contribution to human traits and disease. Nat. Rev. Genet.. 2017; 19: 110 [OpenAIRE] [PubMed] [DOI]

Teumer, A. Genome-wide association study of chronic periodontitis in a general German population. J. Clin. Periodontol.. 2013; 40: 977-985 [OpenAIRE] [PubMed] [DOI]

Shaffer, JR. Genome-wide association study of periodontal health measured by probing depth in adults ages 18–49 years. G3 (Bethesda). 2014; 4: 307-314 [OpenAIRE] [PubMed] [DOI]

Munz, M. A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis. Hum. Molec. Genet. 2018; 26: 2577-2588 [OpenAIRE] [DOI]

Divaris, K. Genome-wide association study of periodontal pathogen colonization. J. Den. Res. 2012; 91: S21-S28 [OpenAIRE] [DOI]

Offenbacher, S. Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease. Hum. Molec. Genet. 2016; 25: 2113-2129 [OpenAIRE] [PubMed] [DOI]

72 references, page 1 of 5
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