publication . Article . Other literature type . 2007

Metabotyping of Caenorhabditis elegans reveals latent phenotypes.

Jean Giacomotto; Benedicte Elena-Herrmann; Marc-Emmanuel Dumas;
Open Access
  • Published: 11 Dec 2007
  • Publisher: Proceedings of the National Academy of Sciences
Abstract
Assigning functions to every gene in a living organism is the next challenge for functional genomics. In fact, 85-90% of the 19,000 genes of the nematode Caenorhabditis elegans genome do not produce any visible phenotype when inactivated, which hampers determining their function, especially when they do not belong to previously characterized gene families. We used (1)H high-resolution magic angle spinning NMR spectroscopy ((1)H HRMAS-NMR) to reveal the latent phenotype associated to superoxide dismutase (sod-1) and catalase (ctl-1) C. elegans mutations, both involved in the elimination of radical oxidative species. These two silent mutations are significantly di...
Subjects
free text keywords: Biological Sciences, MESH: Animals, MESH: Caenorhabditis elegans, MESH: Genome, Helminth, MESH: Genomics, MESH: Magnetic Resonance Spectroscopy, MESH: Mutation, MESH: Oxidative Stress, MESH: Phenotype, MESH: Superoxide Dismutase, [SDV.BC]Life Sciences [q-bio]/Cellular Biology
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