publication . Other literature type . Article . 2007

Oscillating fluid flow activation of gap junction hemichannels induces atp release from MLO-Y4 osteocytes

Clare E. Yellowley; Curtis J. Kephart; Henry J. Donahue; Damian C. Genetos; Yue Zhang;
Open Access
  • Published: 01 Jul 2007
  • Publisher: Wiley
Mechanical loads are required for optimal bone mass. One mechanism whereby mechanical loads are transduced into localized cellular signals is strain-induced fluid flow through lacunae and canaliculi of bone. Gap junctions (GJs) between osteocytes and osteoblasts provides a mechanism whereby flow-induced signals are detected by osteocytes and transduced to osteoblasts. We have demonstrated the importance of GJ and gap junctional intercellular communication (GJIC) in intracellular calcium and prostaglandin E2 (PGE2) increases in response to flow. Unapposed connexons, or hemichannels, are themselves functional and may constitute a novel mechanotransduction mechanis...
Persistent Identifiers
free text keywords: Article, Clinical Biochemistry, Cell Biology, Physiology, Prostaglandin E2, medicine.drug, medicine, Connexon, Protein kinase C, Bone canaliculus, Mechanotransduction, Gap junction, Calcium in biology, Chemistry, Intracellular
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