publication . Article . Other literature type . 2015

cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract

Anahtar, Melis N.; Byrne, Elizabeth H.; Doherty, Kathleen E.; Bowman, Brittany A.; Yamamoto, Hidemi S.; Soumillon, Magali; Padavattan, Nikita; Ismail, Nasreen; Moodley, Amber; Sabatini, Mary E.; ...
Open Access
  • Published: 01 May 2015 Journal: Immunity, volume 42, pages 965-976 (issn: 1074-7613, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Summary Colonization by Lactobacillus in the female genital tract is thought to be critical for maintaining genital health. However, little is known about how genital microbiota influence host immune function and modulate disease susceptibility. We studied a cohort of asymptomatic young South African women and found that the majority of participants had genital communities with low Lactobacillus abundance and high ecological diversity. High-diversity communities strongly correlated with genital pro-inflammatory cytokine concentrations in both cross-sectional and longitudinal analyses. Transcriptional profiling suggested that genital antigen-presenting cells sens...
Subjects
free text keywords: Immune system, Lactobacillus, biology.organism_classification, biology, Vagina, medicine.anatomical_structure, medicine, Cytokine, medicine.medical_treatment, Chemokine, biology.protein, Immunology, Inflammation, medicine.symptom, Disease, Sex organ, Immunology and Allergy, Infectious Diseases, Article
Abstract
Summary Colonization by Lactobacillus in the female genital tract is thought to be critical for maintaining genital health. However, little is known about how genital microbiota influence host immune function and modulate disease susceptibility. We studied a cohort of asymptomatic young South African women and found that the majority of participants had genital communities with low Lactobacillus abundance and high ecological diversity. High-diversity communities strongly correlated with genital pro-inflammatory cytokine concentrations in both cross-sectional and longitudinal analyses. Transcriptional profiling suggested that genital antigen-presenting cells sens...
Subjects
free text keywords: Immune system, Lactobacillus, biology.organism_classification, biology, Vagina, medicine.anatomical_structure, medicine, Cytokine, medicine.medical_treatment, Chemokine, biology.protein, Immunology, Inflammation, medicine.symptom, Disease, Sex organ, Immunology and Allergy, Infectious Diseases, Article
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