publication . Article . 2011

the incidence of necrotizing enterocolitis is increased following probiotic administration to preterm pigs

Cilieborg, Malene Skovsted; Thymann, Thomas; Boye, Mette; Siggers, Richard; Bering, Stine B; Jensen, Bent Borg; Sangild, Per Torp;
Open Access
  • Published: 01 Feb 2011 Journal: The Journal of Nutrition, volume 141, pages 223-230 (issn: 1541-6100, Copyright policy)
  • Publisher: Oxford University Press (OUP)
Abstract
Preterm birth and necrotizing enterocolitis (NEC) is associated with inappropriate gut colonization and immunity, which may be improved by probiotic bacteria. Using a preterm pig model of NEC, we investigated the effects of probiotics on intestinal structure, function, microbiology, and immunology in the immediate postnatal period. Just after birth, caesarean-delivered preterm pigs were inoculated with Lactobacillus paracasei, Bifidobacteria animalis, and Streptococcus thermophilus (total 2.4 × 1010/d) either as live (ProLive, n = 14) or gamma-irradiated dead bacteria (ProDead, n = 12) and compared with controls (n = 14). All pigs received parenteral nutrition f...
Subjects
free text keywords: Nutrition and Dietetics, Medicine (miscellaneous), Enteral administration, Biochemistry, Gastroenterology, medicine.medical_specialty, medicine, Biology, Immune system, Suidae, biology.organism_classification, Necrotizing enterocolitis, medicine.disease, Streptococcus thermophilus, Lactobacillus paracasei, Parenteral nutrition, Internal medicine, Microbiology, Probiotic, law.invention, law
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