publication . Article . Other literature type . 2017

Susceptibility to Mycobacterium ulcerans Disease (Buruli ulcer) Is Associated with IFNG and iNOS Gene Polymorphisms.

Stephanie Bibert; Pierre-Yves Bochud; Dorothy Yeboah-Manu;
Open Access
  • Published: 01 Oct 2017 Journal: Frontiers in Microbiology, volume 8 (eissn: 1664-302X, Copyright policy)
  • Publisher: Frontiers Media SA
Abstract
Buruli ulcer (BU) is a chronic necrotizing disease of the skin and subcutaneous fat tissue. The causative agent, Mycobacterium ulcerans, produces mycolactone, a macrolide toxin, which causes apoptosis of mammalian cells. Only a small proportion of individuals exposed to M. ulcerans develop clinical disease, as surrounding macrophages may control the infection by bacterial killing at an early stage, while mycolactone concentration is still low. Otherwise, bacterial multiplication leads to in higher concentrations of mycolactone, with formation of necrotizing lesions that are no more accessible to immune cells. By typing a cohort of 96 Ghanaian BU patients and 384...
Subjects
free text keywords: Buruli ulcer; Mycobacterium ulcerans; immunogenetics; infectious diseases; single nucleotide polymorphism, Microbiology (medical), Microbiology, Original Research, immunogenetics, Buruli ulcer, Mycobacterium ulcerans, infectious diseases, single nucleotide polymorphism, QR1-502
76 references, page 1 of 6

Abel L.Sanchez F. O.Oberti J.Thuc N. V.Hoa L. V.Lap V. D. (1998). Susceptibility to leprosy is linked to the human NRAMP1 gene. J. Infect. Dis. 177 133–145. 10.1086/513830 9419180 [OpenAIRE] [PubMed] [DOI]

Amofah G. K.Sagoe-Moses C.Adjei-Acquah C.Frimpong E. H. (1993). Epidemiology of Buruli ulcer in Amansie West district, Ghana. Trans. R. Soc. Trop. Med. Hyg. 87 644–645. 10.1016/0035-9203(93)90272-R 8296362 [PubMed] [DOI]

Barogui Y. T.Klis S. A.Johnson R. C.Phillips R. O.van der Veer E.van Diemen C. (2016). Genetic susceptibility and predictors of paradoxical reactions in Buruli Ulcer. PLOS Negl. Trop. Dis. 10:e0004594 10.1371/journal.pntd.0004594 [OpenAIRE] [DOI]

Bellamy R. (1998). Genetics and pulmonary medicine. 3. Genetic susceptibility to tuberculosis in human populations. Thorax 53 588–593. 10.1136/thx.53.7.588 9797 760 [OpenAIRE] [PubMed] [DOI]

Bellamy R. (1999). The natural resistance-associated macrophage protein and susceptibility to intracellular pathogens. Microbes Infect. Instit. Past. 1 23–27. 10.1016/S1286-4579(99)80010-0 [DOI]

Bellamy R. (2000). Identifying genetic susceptibility factors for tuberculosis in Africans: a combined approach using a candidate gene study and a genome-wide screen. Clin. Sci. 98 245–250.10677381 [PubMed]

Bellamy R.Ruwende C.Corrah T.McAdam K. P.Whittle H. C.Hill A. V. (1998). Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans. N. Engl. J. Med. 338 640–644. 10.1056/NEJM1998030533810 02 9486992 [OpenAIRE] [PubMed] [DOI]

Bieri R.Bolz M.Ruf M. T.Pluschke G. (2016). Interferon-gamma is a crucial activator of early host immune defense against Mycobacterium ulcerans infection in mice. PLOS Neglect. Trop. Dis. 10:e0004450 10.1371/journal.pntd.0004450 [OpenAIRE] [DOI]

Bieri R.Scherr N.Ruf M. T.Dangy J. P.Gersbach P.Gehringer M. (2017). The macrolide toxin mycolactone promotes bim-dependent apoptosis in Buruli Ulcer through inhibition of mTOR. ACS Chem. Biol. 12 1297–1307. 10.1021/acschembio.7b00053 28294596 [OpenAIRE] [PubMed] [DOI]

Bolz M.Ruggli N.Borel N.Pluschke G.Ruf M. T. (2016). Local cellular immune responses and pathogenesis of Buruli Ulcer lesions in the experimental Mycobacterium ulcerans pig infection model. PLOS Neglect. Trop. Dis. 10:e0004678 10.1371/journal.pntd.0004678 [OpenAIRE] [DOI]

Boulkroun S.Guenin-Mace L.Thoulouze M. I.Monot M.Merckx A.Langsley G. (2010). Mycolactone suppresses T cell responsiveness by altering both early signaling and posttranslational events. J. Immunol. 184 1436–1444. 10.4049/jimmunol.0902854 20042571 [OpenAIRE] [PubMed] [DOI]

Boutlis C. S.Hobbs M. R.Marsh R. L.Misukonis M. A.Tkachuk A. N.Lagog M. (2003). Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population. Am. J. Trop. Med. Hyg. 69 569–573.14740870 [OpenAIRE] [PubMed]

Bratschi M. W.Bolz M.Minyem J. C.Grize L.Wantong F. G.Kerber S. (2013). Geographic distribution, age pattern and sites of lesions in a cohort of Buruli ulcer patients from the Mape Basin of Cameroon. PLOS Negl. Trop. Dis. 7:e2252 10.1371/journal.pntd.0002252 [OpenAIRE] [DOI]

Burgner D.Usen S.Rockett K.Jallow M.Ackerman H.Cervino A. (2003). Nucleotide and haplotypic diversity of the NOS2A promoter region and its relationship to cerebral malaria. Hum. Genet. 112 379–386.12552317 [PubMed]

Burgner D.Xu W.Rockett K.Gravenor M.Charles I. G.Hill A. V. (1998). Inducible nitric oxide synthase polymorphism and fatal cerebral malaria. Lancet 352 1193–1194. 10.1016/S0140-6736(05)60531-4 9777841 [OpenAIRE] [PubMed] [DOI]

76 references, page 1 of 6
Abstract
Buruli ulcer (BU) is a chronic necrotizing disease of the skin and subcutaneous fat tissue. The causative agent, Mycobacterium ulcerans, produces mycolactone, a macrolide toxin, which causes apoptosis of mammalian cells. Only a small proportion of individuals exposed to M. ulcerans develop clinical disease, as surrounding macrophages may control the infection by bacterial killing at an early stage, while mycolactone concentration is still low. Otherwise, bacterial multiplication leads to in higher concentrations of mycolactone, with formation of necrotizing lesions that are no more accessible to immune cells. By typing a cohort of 96 Ghanaian BU patients and 384...
Subjects
free text keywords: Buruli ulcer; Mycobacterium ulcerans; immunogenetics; infectious diseases; single nucleotide polymorphism, Microbiology (medical), Microbiology, Original Research, immunogenetics, Buruli ulcer, Mycobacterium ulcerans, infectious diseases, single nucleotide polymorphism, QR1-502
76 references, page 1 of 6

Abel L.Sanchez F. O.Oberti J.Thuc N. V.Hoa L. V.Lap V. D. (1998). Susceptibility to leprosy is linked to the human NRAMP1 gene. J. Infect. Dis. 177 133–145. 10.1086/513830 9419180 [OpenAIRE] [PubMed] [DOI]

Amofah G. K.Sagoe-Moses C.Adjei-Acquah C.Frimpong E. H. (1993). Epidemiology of Buruli ulcer in Amansie West district, Ghana. Trans. R. Soc. Trop. Med. Hyg. 87 644–645. 10.1016/0035-9203(93)90272-R 8296362 [PubMed] [DOI]

Barogui Y. T.Klis S. A.Johnson R. C.Phillips R. O.van der Veer E.van Diemen C. (2016). Genetic susceptibility and predictors of paradoxical reactions in Buruli Ulcer. PLOS Negl. Trop. Dis. 10:e0004594 10.1371/journal.pntd.0004594 [OpenAIRE] [DOI]

Bellamy R. (1998). Genetics and pulmonary medicine. 3. Genetic susceptibility to tuberculosis in human populations. Thorax 53 588–593. 10.1136/thx.53.7.588 9797 760 [OpenAIRE] [PubMed] [DOI]

Bellamy R. (1999). The natural resistance-associated macrophage protein and susceptibility to intracellular pathogens. Microbes Infect. Instit. Past. 1 23–27. 10.1016/S1286-4579(99)80010-0 [DOI]

Bellamy R. (2000). Identifying genetic susceptibility factors for tuberculosis in Africans: a combined approach using a candidate gene study and a genome-wide screen. Clin. Sci. 98 245–250.10677381 [PubMed]

Bellamy R.Ruwende C.Corrah T.McAdam K. P.Whittle H. C.Hill A. V. (1998). Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans. N. Engl. J. Med. 338 640–644. 10.1056/NEJM1998030533810 02 9486992 [OpenAIRE] [PubMed] [DOI]

Bieri R.Bolz M.Ruf M. T.Pluschke G. (2016). Interferon-gamma is a crucial activator of early host immune defense against Mycobacterium ulcerans infection in mice. PLOS Neglect. Trop. Dis. 10:e0004450 10.1371/journal.pntd.0004450 [OpenAIRE] [DOI]

Bieri R.Scherr N.Ruf M. T.Dangy J. P.Gersbach P.Gehringer M. (2017). The macrolide toxin mycolactone promotes bim-dependent apoptosis in Buruli Ulcer through inhibition of mTOR. ACS Chem. Biol. 12 1297–1307. 10.1021/acschembio.7b00053 28294596 [OpenAIRE] [PubMed] [DOI]

Bolz M.Ruggli N.Borel N.Pluschke G.Ruf M. T. (2016). Local cellular immune responses and pathogenesis of Buruli Ulcer lesions in the experimental Mycobacterium ulcerans pig infection model. PLOS Neglect. Trop. Dis. 10:e0004678 10.1371/journal.pntd.0004678 [OpenAIRE] [DOI]

Boulkroun S.Guenin-Mace L.Thoulouze M. I.Monot M.Merckx A.Langsley G. (2010). Mycolactone suppresses T cell responsiveness by altering both early signaling and posttranslational events. J. Immunol. 184 1436–1444. 10.4049/jimmunol.0902854 20042571 [OpenAIRE] [PubMed] [DOI]

Boutlis C. S.Hobbs M. R.Marsh R. L.Misukonis M. A.Tkachuk A. N.Lagog M. (2003). Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population. Am. J. Trop. Med. Hyg. 69 569–573.14740870 [OpenAIRE] [PubMed]

Bratschi M. W.Bolz M.Minyem J. C.Grize L.Wantong F. G.Kerber S. (2013). Geographic distribution, age pattern and sites of lesions in a cohort of Buruli ulcer patients from the Mape Basin of Cameroon. PLOS Negl. Trop. Dis. 7:e2252 10.1371/journal.pntd.0002252 [OpenAIRE] [DOI]

Burgner D.Usen S.Rockett K.Jallow M.Ackerman H.Cervino A. (2003). Nucleotide and haplotypic diversity of the NOS2A promoter region and its relationship to cerebral malaria. Hum. Genet. 112 379–386.12552317 [PubMed]

Burgner D.Xu W.Rockett K.Gravenor M.Charles I. G.Hill A. V. (1998). Inducible nitric oxide synthase polymorphism and fatal cerebral malaria. Lancet 352 1193–1194. 10.1016/S0140-6736(05)60531-4 9777841 [OpenAIRE] [PubMed] [DOI]

76 references, page 1 of 6
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue