publication . Article . Other literature type . 2007

Clathrate nanostructures for mass spectrometry

Oscar Yanes; Michael T. Northen; Gary Siuzdak; Anders Nordström; Dena Marrinucci; Stephen L. Golledge; Trent R. Northen; Winnie Uritboonthai; Junefredo V. Apon;
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  • Published: 01 Oct 2007 Journal: Nature, volume 449, pages 1,033-1,036 (issn: 0028-0836, eissn: 1476-4687, Copyright policy)
  • Publisher: Island Press
Abstract
The ability of mass spectrometry to generate intact biomolecular ions efficiently in the gas phase has led to its widespread application in metabolomics, proteomics, biological imaging, biomarker discovery and clinical assays (namely neonatal screens). Matrix-assisted laser desorption/ionization (MALDI) and electrospray ionization have been at the forefront of these developments. However, matrix application complicates the use of MALDI for cellular, tissue, biofluid and microarray analysis and can limit the spatial resolution because of the matrix crystal size (typically more than 10 mum), sensitivity and detection of small compounds (less than 500 Da). Secondar...
Subjects
free text keywords: Multidisciplinary, Ionization, MALDI imaging, Chemistry, Surface-enhanced laser desorption/ionization, Metabolomics, Mass spectrometry, Capillary electrophoresis–mass spectrometry, Proteomics, Electrospray ionization, Analytical chemistry
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