publication . Article . Other literature type . 2010

CD147-cyclophilin interactions

V Yurchenko; S Constant; E Eisenmesser; M Bukrinsky;
Open Access
  • Published: 01 Jun 2010 Journal: Clinical & Experimental Immunology, volume 160, pages 305-317 (issn: 0009-9104, eissn: 1365-2249, Copyright policy)
  • Publisher: Wiley
Abstract
CD147 is a widely expressed plasma membrane protein that has been implicated in a variety of physiological and pathological activities. It is best known for its ability to function as extracellular matrix metalloproteinase inducer (hence the other name for this protein, EMMPRIN), but has also been shown to regulate lymphocyte responsiveness, monocarboxylate transporter expression and spermatogenesis. These functions reflect multiple interacting partners of CD147. Among these CD147-interacting proteins cyclophilins represent a particularly interesting class, both in terms of structural considerations and potential medical implications. CD147 has been shown to fun...
Subjects
free text keywords: Cyclophilin, Chemotaxis, Receptor, Immune system, Inflammation, medicine.symptom, medicine, Monocarboxylate transporter, biology.protein, biology, Extracellular, Metalloproteinase, Immunology, Review Articles
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