publication . Article . Review . Other literature type . 2012

Lung damage and airway remodelling in severe asthma.

chris brightling; Salman Siddiqui; Sumit Gupta;
Restricted
  • Published: 01 Jan 2012 Journal: Clinical & Experimental Allergy, volume 42, pages 638-649 (issn: 0954-7894, Copyright policy)
  • Publisher: Wiley
Abstract
Summary Severe asthma is a heterogeneous disease with substantial unmet clinical need. Airway damage and remodelling is a consequence of complex host–environment interactions and is considered to be the cardinal feature leading onto the development and persistence of airflow obstruction. In this review, we shall bring together recent insights into the causes of airway damage and remodelling that propose key roles for pathogens and mechanical damage in addition to allergens, underlying genetic susceptibility, inflammatory and structural cell interactions, and impaired resolution of damage. We shall consider the consequences of airway remodelling in terms of airwa...
Subjects
Medical Subject Headings: respiratory tract diseasesrespiratory system
free text keywords: Immunology, Immunology and Allergy
Funded by
EC| AIRPROM
Project
AIRPROM
Airway Disease PRedicting Outcomes through Patient Specific Computational Modelling
  • Funder: European Commission (EC)
  • Project Code: 270194
  • Funding stream: FP7 | SP1 | ICT
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