publication . Article . 2011

Variation in global codon usage bias among prokaryotic organisms is associated with their lifestyles

Maya Botzman; Hanah Margalit;
Open Access
  • Published: 01 Oct 2011 Journal: Genome Biology, volume 12, page R109 (issn: 1465-6906, Copyright policy)
  • Publisher: Springer Nature
Background It is widely acknowledged that synonymous codons are used unevenly among genes in a genome. In organisms under translational selection, genes encoding highly expressed proteins are enriched with specific codons. This phenomenon, termed codon usage bias, is common to many organisms and has been recognized as influencing cellular fitness. This suggests that the global extent of codon usage bias of an organism might be associated with its phenotypic traits. Results To test this hypothesis we used a simple measure for assessing the extent of codon bias of an organism, and applied it to hundreds of sequenced prokaryotes. Our analysis revealed a large varia...
free text keywords: Research, Organism, Codon usage bias, Human genetics, Phenotype, Biology, Genetics, Phylogenetics, Gene, Genome, Phenotypic trait
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