publication . Article . 2007

Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone.

Nathalie WINTER; Caroline Demangel;
Open Access
  • Published: 11 Jun 2007 Journal: Journal of Experimental Medicine, volume 204, pages 1,395-1,403 (issn: 0022-1007, eissn: 1540-9538, Copyright policy)
  • Publisher: Rockefeller University Press
Abstract
International audience; Mycolactone is a polyketide toxin produced by Mycobacterium ulcerans (Mu), the causative agent of the skin disease Buruli ulcer (BU). Surprisingly, infected tissues lack inflammatory infiltrates. Structural similarities between mycolactone and immunosuppressive agents led us to investigate the immunomodulatory properties of mycolactone on dendritic cells (DCs), the key initiators and regulators of immune responses. At noncytotoxic concentrations, phenotypic and functional maturation of both mouse and human DCs was inhibited by mycolactone. Notably, mycolactone blocked the emigration of mouse-skin DCs to draining lymph nodes, as well as th...
Subjects
free text keywords: Immunology, Immunology and Allergy, Articles, Article, POLYKETIDE TOXIN, CHEMOKINES, INTERFERON, BURULI ULCER, IMMUNE-RESPONSE, MACROLIDE TOXIN, INFECTION, TUBERCULOSIS, EXPRESSION, EVOLUTION, [SDV.IMM]Life Sciences [q-bio]/Immunology, Microbiologie et Parasitologie, Microbiology and Parasitology, BURULI ULCER;IMMUNE-RESPONSE;POLYKETIDE TOXIN;MACROLIDE TOXIN;INFECTION;CHEMOKINES;TUBERCULOSIS;INTERFERON;EXPRESSION;EVOLUTION, mycotoxine, interleukine, cellule dendritique, mycobacterium, réponse immunitaire
Funded by
NIH| Mycolactone-Mediated Virulence in M. ulcerans
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01AI049418-03
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| TB Research Materials and Vaccine testing-26675320
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: N01AI075320-009
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
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