publication . Other literature type . Article . 2008

The Conserved Proteins CHE-12 and DYF-11 Are Required for Sensory Cilium Function in Caenorhabditis elegans

Taulant Bacaj; Yun Lu; Shai Shaham;
Open Access English
  • Published: 01 Feb 2008
  • Publisher: Genetics Society of America
Abstract
Sensory neuron cilia are evolutionarily conserved dendritic appendages that convert environmental stimuli into neuronal activity. Although several cilia components are known, the functions of many remain uncharacterized. Furthermore, the basis of morphological and functional differences between cilia remains largely unexplored. To understand the molecular basis of cilia morphogenesis and function, we studied the Caenorhabditis elegans mutants che-12 and dyf-11. These mutants fail to concentrate lipophilic dyes from their surroundings in sensory neurons and are chemotaxis defective. In che-12 mutants, sensory neuron cilia lack distal segments, while in dyf-11 ani...
Subjects
Medical Subject Headings: sense organs
free text keywords: Investigations, Genetics, Cilium, Amphid, Chemotaxis, Morphogenesis, Caenorhabditis elegans, biology.organism_classification, biology, Intraflagellar transport, Conserved sequence, Sensory neuron, medicine.anatomical_structure, medicine
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Other literature type . 2008
Genetics
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publication . Other literature type . Article . 2008

The Conserved Proteins CHE-12 and DYF-11 Are Required for Sensory Cilium Function in Caenorhabditis elegans

Taulant Bacaj; Yun Lu; Shai Shaham;